EC Number | Application | Comment | Organism |
---|---|---|---|
1.4.3.2 | medicine | LAO potently induces lesions in lungs and livers. LAO causes severe pneumorrhagia, pulmonary interstitial edema, fusion of pulmonary alveoli, cardiac interstitial edema and bleeding when being intravenously injected into BALB/c mice. Also induces liver cell necrosis and release of cytokines including IL-6, IL-12 and IL-2 from highly purified human peripheral blood monocytes and T cells, respectively. The ability of LAO will contribute to the understanding of the pathogenesis of snakebite wound | Gloydius ussuriensis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.4.3.2 | 0.11 | - |
L-leucine | - |
Gloydius ussuriensis | |
1.4.3.2 | 0.27 | - |
L-valine | - |
Gloydius ussuriensis | |
1.4.3.2 | 0.36 | - |
L-asparagine | - |
Gloydius ussuriensis | |
1.4.3.2 | 0.88 | - |
L-methionine | - |
Gloydius ussuriensis | |
1.4.3.2 | 0.97 | - |
L-lysine | - |
Gloydius ussuriensis | |
1.4.3.2 | 1.57 | - |
L-tyrosine | - |
Gloydius ussuriensis | |
1.4.3.2 | 2.3 | - |
L-tryptophan | - |
Gloydius ussuriensis | |
1.4.3.2 | 2.33 | - |
L-arginine | - |
Gloydius ussuriensis | |
1.4.3.2 | 4.02 | - |
L-isoleucine | - |
Gloydius ussuriensis | |
1.4.3.2 | 4.28 | - |
L-phenylalanine | - |
Gloydius ussuriensis | |
1.4.3.2 | 4.97 | - |
L-histidine | - |
Gloydius ussuriensis | |
1.4.3.2 | 5.12 | - |
L-alanine | - |
Gloydius ussuriensis |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.4.3.2 | 58000 | - |
2 * 60000, SDS-PAGE under reducing conditions, 2 * 58000, SDS-PAGE under nonreducing conditions | Gloydius ussuriensis |
1.4.3.2 | 60000 | - |
2 * 60000, SDS-PAGE under reducing conditions, 2 * 58000, SDS-PAGE under nonreducing conditions | Gloydius ussuriensis |
1.4.3.2 | 108800 | - |
gel filtration | Gloydius ussuriensis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.4.3.2 | Gloydius ussuriensis | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.4.3.2 | by gel filtration followed by ion-exchange chromatography, 51.3fold | Gloydius ussuriensis |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.4.3.2 | venom | - |
Gloydius ussuriensis | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.4.3.2 | 1.56 | - |
crude venom | Gloydius ussuriensis |
1.4.3.2 | 79.92 | - |
51.3fold purified | Gloydius ussuriensis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.4.3.2 | L-alanine + H2O + O2 | - |
Gloydius ussuriensis | 2-oxopropanoic acid + NH3 + H2O2 | - |
? | |
1.4.3.2 | L-arginine + H2O + O2 | - |
Gloydius ussuriensis | 2-oxo-5-guanidinovaleric acid + NH3 + H2O2 | - |
? | |
1.4.3.2 | L-asparagine + H2O + O2 | - |
Gloydius ussuriensis | alpha-ketosuccinamic acid + NH3 + H2O2 | - |
? | |
1.4.3.2 | L-histidine + H2O + O2 | - |
Gloydius ussuriensis | 3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2 | - |
? | |
1.4.3.2 | L-isoleucine + H2O + O2 | - |
Gloydius ussuriensis | 3-methyl-2-oxopentanoic acid + NH3 + H2O2 | - |
? | |
1.4.3.2 | L-leucine + H2O + O2 | - |
Gloydius ussuriensis | 4-methyl-2-oxopentanoic acid + NH3 + H2O2 | - |
? | |
1.4.3.2 | L-lysine + H2O + O2 | - |
Gloydius ussuriensis | 6-amino-2-oxohexanoic acid + NH3 + H2O2 | - |
? | |
1.4.3.2 | L-methionine + H2O + O2 | - |
Gloydius ussuriensis | 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2 | - |
? | |
1.4.3.2 | L-phenylalanine + H2O + O2 | - |
Gloydius ussuriensis | phenylpyruvate + NH3 + H2O2 | - |
? | |
1.4.3.2 | L-tryptophan + H2O + O2 | - |
Gloydius ussuriensis | 3-indole-2-oxopropanoate + NH3 + H2O2 | - |
? | |
1.4.3.2 | L-tyrosine + H2O + O2 | - |
Gloydius ussuriensis | p-hydroxyphenylpyruvate + NH3 + H2O2 | - |
? | |
1.4.3.2 | L-valine + H2O + O2 | - |
Gloydius ussuriensis | 2-oxoisovalerate + NH3 + H2O2 | - |
? | |
1.4.3.2 | additional information | does not hydrolyze casein and synthetic substrates including N-benzoyl-L-arginine ethylester or N-benzoyl-L-arginine p-nitroanilide | Gloydius ussuriensis | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.4.3.2 | dimer | 2 * 60000, SDS-PAGE under reducing conditions, 2 * 58000, SDS-PAGE under nonreducing conditions | Gloydius ussuriensis |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.4.3.2 | LAO | - |
Gloydius ussuriensis |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.4.3.2 | 4.15 | - |
L-histidine | - |
Gloydius ussuriensis | |
1.4.3.2 | 5.08 | - |
L-valine | - |
Gloydius ussuriensis | |
1.4.3.2 | 5.26 | - |
L-asparagine | - |
Gloydius ussuriensis | |
1.4.3.2 | 6.33 | - |
L-isoleucine | - |
Gloydius ussuriensis | |
1.4.3.2 | 6.58 | - |
L-tryptophan | - |
Gloydius ussuriensis | |
1.4.3.2 | 8.42 | - |
L-tyrosine | - |
Gloydius ussuriensis | |
1.4.3.2 | 10.51 | - |
L-lysine | - |
Gloydius ussuriensis | |
1.4.3.2 | 22.54 | - |
L-arginine | - |
Gloydius ussuriensis | |
1.4.3.2 | 24.13 | - |
L-methionine | - |
Gloydius ussuriensis | |
1.4.3.2 | 26.89 | - |
L-alanine | - |
Gloydius ussuriensis | |
1.4.3.2 | 48.22 | - |
L-leucine | - |
Gloydius ussuriensis | |
1.4.3.2 | 48.23 | - |
L-phenylalanine | - |
Gloydius ussuriensis |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.4.3.2 | 5.2 | - |
- |
Gloydius ussuriensis |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
1.4.3.2 | 4.4 | 9.6 | - |
Gloydius ussuriensis |