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Literature summary extracted from

  • Stiborova, M.; Dracinska, H.; Mizerovska, J.; Frei, E.; Schmeiser, H.H.; Hudecek, J.; Hodek, P.; Phillips, D.H.; Arlt, V.M.
    The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity (2008), Toxicology, 247, 11-22.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.5.2 3-nitrobenzanthrone increases protein level and enzymatic activity of NQO1. Up to a 2.5fold increase in NQO1 activity with menadione as substrate in tissues of rats treated with 3-nitrobenzanthrone Rattus norvegicus

Application

EC Number Application Comment Organism
1.6.5.2 medicine 3-nitrobenzanthrone is capable to induce NQO1 and CYP1A1 in lungs and kidney of rats thereby enhancing its own genotoxic and carcinogenic potential Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.5.2 dicoumarol
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.5.2 cytosol
-
 Rattus norvegicus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.2 Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.2 kidney
-
 Rattus norvegicus
-
1.6.5.2 lung
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.6.5.2 0.05
-
 in lung of control rats Rattus norvegicus
1.6.5.2 0.06
-
 in lung of rats treated with 0.4 or 4 mg/kg of 3-nitrobenzanthrone Rattus norvegicus
1.6.5.2 0.09
-
 in kidney of control rats and in lung of rats treated with 40 mg/kg of 3-nitrobenzanthrone Rattus norvegicus
1.6.5.2 0.15
-
 in kidney of rats treated with 0.4 or 4 mg/kg of 3-nitrobenzanthrone Rattus norvegicus
1.6.5.2 0.23
-
 in kidney of rats treated with 40 mg/kg of 3-nitrobenzanthrone Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.2 menadione + NADPH
-
 Rattus norvegicus reduced menadione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.6.5.2 NAD(P)H:quinone oxidoreductase
-
 Rattus norvegicus
1.6.5.2 NQO1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.5.2 NADPH
-
 Rattus norvegicus