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Literature summary extracted from

  • Muniz Ortiz, J.G.; Opoka, R.; Kane, D.; Cartwright, I.L.
    Investigating arsenic susceptibility from a genetic perspective in Drosophila reveals a key role for glutathione synthetase (2008), Toxicol. Sci., 107, 416-426.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.2.3 GS gene, located at chromosome 16F1, mapping of an X-linked arsenite-tolerance component to subdivision 16, overview Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
6.3.2.3 additional information creation of targeted X chromosomal deficiency lines. Relative arsenite sensitivity arises when the dose of the glutathione synthetase gene expression is reduced by half. Knockdown of GS expression by RNAi in cultured S2 cells leads to enhanced arsenite sensitivity, while GS RNAi applied to intact organisms dramatically reduces the concentration of food-borne arsenite compatible with successful growth and development, phenotypes, overview Drosophila melanogaster

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.2.3 Mg2+
-
 Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.3 ATP + gamma-L-glutamyl-L-cysteine + glycine Drosophila melanogaster an optimally functioning two-step glutathione biosynthetic pathway is required in vivo for a robust defense against arsenite ADP + phosphate + glutathione
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.3 Drosophila melanogaster
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.3 ATP + gamma-L-glutamyl-L-cysteine + glycine
-
 Drosophila melanogaster ADP + phosphate + glutathione
-
 ?
6.3.2.3 ATP + gamma-L-glutamyl-L-cysteine + glycine an optimally functioning two-step glutathione biosynthetic pathway is required in vivo for a robust defense against arsenite Drosophila melanogaster ADP + phosphate + glutathione
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.3 Glutathione synthetase
-
 Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.2.3 ATP
-
 Drosophila melanogaster