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Literature summary extracted from

  • Bevan, S.; Dichgans, M.; Wiechmann, H.E.; Gschwendtner, A.; Meitinger, T.; Markus, H.S.
    Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations (2008), Stroke, 39, 1109-1114.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
4.4.1.20 additional information the LTC4S2 variant in LTC4 confers a 1.807fold increase in stroke when present at 2 copies, whereas the LTBR_2 variant in the LTB4R/LTB4R2 gene region confers a 1.671fold increase in stroke risk when present at 1 or more copies, LTBR_2 and LTBR_6, confer relative risks of 2.371 and 2.081 in cardioembolic stroke, variants in leukotriene C4 synthase confer a 1.5fold increase in risk of small vessel disease Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.20 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.20 blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.20 leukotriene A4 + glutathione
-
 Homo sapiens leukotriene C4 + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.20 leukotriene C4 synthase
-
 Homo sapiens
4.4.1.20 LTC4 synthase
-
 Homo sapiens
4.4.1.20 LTC4S
-
 Homo sapiens