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Literature summary extracted from

  • Shackleton, C.H.; Neres, M.S.; Hughes, B.A.; Stewart, P.M.; Kater, C.E.
    17-Hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites (2008), Steroids, 73, 652-656.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.19 additional information complete 17-hydroxylase deficiency, 17HD, does not play a role in C19 steroid metabolism, but cortisol-treated 17HD patients cannot produce androstenedione, phenotype, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.32 17alpha-Hydroxypregnenolone Homo sapiens 17,20-lyase activity Dehydroepiandrosterone + acetaldehyde
-
 ?
1.14.14.32 17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens 17,20-lyase activity androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.19 Homo sapiens
-
-
-
1.14.14.32 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.19 additional information CYP17 does not perform side-chain cleavage of cortisol and its metabolites, e.g. 11-oxo-etiocholanolone and 11beta-hydroxyetiocholanolone Homo sapiens ?
-
 ?
1.14.14.32 17alpha-Hydroxypregnenolone 17,20-lyase activity Homo sapiens Dehydroepiandrosterone + acetaldehyde
-
 ?
1.14.14.32 17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2 17,20-lyase activity Homo sapiens androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.19 17-hydroxylase/C17,20-lyase
-
 Homo sapiens
1.14.14.19 CYP17
-
 Homo sapiens
1.14.14.32 17-hydroxylase/C17,20-lyase
-
 Homo sapiens
1.14.14.32 CYP17
-
 Homo sapiens