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Literature summary extracted from

  • Chen, R.; Liao, Z.H.; Chen, M.; Wang, Q.; Yang, C.X.; Yang, Y.J.
    Molecular cloning and characterization of the strictosidine synthase gene from Rauwolfia verticillata (2008), Russ. J. Plant Physiol., 55, 670-675.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.3.3.2 gene RvSTR, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis Rauvolfia verticillata

Protein Variants

EC Number Protein Variants Comment Organism
4.3.3.2 biotechnology the enzyme encoding gene is a candidate gene for metabolic engineering of the TIA pathway in Rauwolfia verticillata Rauvolfia verticillata

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.3.3.2 38200
-
 x * 38200, about, sequence calculation Rauvolfia verticillata

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.3.2 tryptamine + secologanin Rauvolfia verticillata the strictosidine synthase catalyzes the condensation of tryptamine and secologanin to form strictosidine, which is the universal precursor for a wide range of pharmaceutical terpenoid indole alkaloids, TIA, e.g. in biosynthesis of reserpine and ajmalicine from the Chinese native TIAs-producing plant, overview 3-alpha(S)-strictosidine + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.3.3.2 Rauvolfia verticillata Q1L6F4
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.3.3.2 flower
-
 Rauvolfia verticillata
-
4.3.3.2 fruit
-
 Rauvolfia verticillata
-
4.3.3.2 leaf
-
 Rauvolfia verticillata
-
4.3.3.2 additional information tissue expression pattern analysis, overview Rauvolfia verticillata
-
4.3.3.2 root
-
 Rauvolfia verticillata
-
4.3.3.2 stem
-
 Rauvolfia verticillata
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.3.2 tryptamine + secologanin the strictosidine synthase catalyzes the condensation of tryptamine and secologanin to form strictosidine, which is the universal precursor for a wide range of pharmaceutical terpenoid indole alkaloids, TIA, e.g. in biosynthesis of reserpine and ajmalicine from the Chinese native TIAs-producing plant, overview Rauvolfia verticillata 3-alpha(S)-strictosidine + H2O
-
 ?
4.3.3.2 tryptamine + secologanin the unique essential and conserved catalytic residue is Glu309 Rauvolfia verticillata 3-alpha(S)-strictosidine + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
4.3.3.2 ? x * 38200, about, sequence calculation Rauvolfia verticillata

Synonyms

EC Number Synonyms Comment Organism
4.3.3.2 str
-
 Rauvolfia verticillata

pI Value

EC Number Organism Comment pI Value Maximum pI Value
4.3.3.2 Rauvolfia verticillata sequence calculation
-
 5.19