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Literature summary extracted from

  • Ryzhov, S.; Zaynagetdinov, R.; Goldstein, A.E.; Matafonov, A.; Biaggioni, I.; Feoktistov, I.
    Differential role of the carboxy-terminus of the A(2B) adenosine receptor in stimulation of adenylate cyclase, phospholipase Cbeta, and interleukin-8 (2009), Purinergic Signal., 5, 289-298.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.1 A2B adenosine receptor activates the enzyme and regulates its activity and the cAMP signaling pathway in mast and microvascular cell, role of the C-terminus of the A2B receptor in stimulation of adenylate cyclase, which is important for A2B receptor coupling to Gs-adenylate cyclase, overview Cricetulus griseus
4.6.1.1 A2B adenosine receptor activates the enzyme and regulates its activity and the cAMP signaling pathway in mast and microvascular cell, role of the C-terminus of the A2B receptor in stimulation of adenylate cyclase, which is important for A2B receptor coupling to Gs-adenylate cyclase, overview Homo sapiens
4.6.1.1 forskolin free G protein Gsalpha subunits enhance adenylate cyclase responses to forskolin Cricetulus griseus
4.6.1.1 forskolin free G protein Gsalpha subunits enhance adenylate cyclase responses to forskolin Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.1 membrane
-
 Cricetulus griseus 16020
-
4.6.1.1 membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.1 ATP Cricetulus griseus
-
 3',5'-cyclic-AMP + diphosphate
-
 ?
4.6.1.1 ATP Homo sapiens
-
 3',5'-cyclic-AMP + diphosphate
-
 ?
4.6.1.1 additional information Cricetulus griseus the A2B adenosine receptor controls at least three independent signaling pathways, one of which is the Gs-mediated stimulation of adenylate cyclase, in mast cells and microvascular endothelial cells ?
-
 ?
4.6.1.1 additional information Homo sapiens the A2B adenosine receptor controls at least three independent signaling pathways, one of which is the Gs-mediated stimulation of adenylate cyclase, in mast cells and microvascular endothelial cells ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Cricetulus griseus
-
-
-
4.6.1.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.1 CHO cell
-
 Cricetulus griseus
-
4.6.1.1 HEK-293 cell
-
 Homo sapiens
-
4.6.1.1 mast cell
-
 Homo sapiens
-
4.6.1.1 microvascular endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.1 ATP
-
 Cricetulus griseus 3',5'-cyclic-AMP + diphosphate
-
 ?
4.6.1.1 ATP
-
 Homo sapiens 3',5'-cyclic-AMP + diphosphate
-
 ?
4.6.1.1 additional information the A2B adenosine receptor controls at least three independent signaling pathways, one of which is the Gs-mediated stimulation of adenylate cyclase, in mast cells and microvascular endothelial cells Cricetulus griseus ?
-
 ?
4.6.1.1 additional information the A2B adenosine receptor controls at least three independent signaling pathways, one of which is the Gs-mediated stimulation of adenylate cyclase, in mast cells and microvascular endothelial cells Homo sapiens ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.6.1.1 37
-
 assay at Cricetulus griseus
4.6.1.1 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.6.1.1 7.4
-
 assay at Cricetulus griseus
4.6.1.1 7.4
-
 assay at Homo sapiens