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Literature summary extracted from

  • Glisic, S.; Arrigo, P.; Alavantic, D.; Perovic, V.; Prljic, J.; Veljkovic, N.
    Lipoprotein lipase: A bioinformatics criterion for assessment of mutations as a risk factor for cardiovascular disease (2008), Proteins Struct. Funct. Bioinform., 70, 855-862.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.1.34 medicine LPL mutations represent a risk factor which contributes to the development of cardiovascular disease Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.34 D9N the mutation is associated with partial changes in enzyme function, plasma high density lipoprotein-C, triglyceride levels, and differential susceptibility to cardiovascular disease Homo sapiens
3.1.1.34 N291S the mutation is associated with partial changes in enzyme function, plasma high density lipoprotein-C, triglyceride levels, and differential susceptibility to cardiovascular disease Homo sapiens
3.1.1.34 S447X the mutation results in truncation of the last two amino acids of the mature LPL and is the only mutation reported to increase enzymatic activity, the mutation is associated with differential susceptibility to cardiovascular disease Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.34 Homo sapiens P06858
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.34 chylomicron + H2O
-
 Homo sapiens ?
-
 ?
3.1.1.34 triacylglycerol + H2O catalyzes the hydrolysis of triglycerides in circulating chylomicrons and very-low density lipoproteins Homo sapiens diacylglycerol + a carboxylate
-
 ?
3.1.1.34 triolein + H2O
-
 Homo sapiens oleate + diolein
-
 ?
3.1.1.34 very low density protein + H2O
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.34 homodimer dissociation of the dimeric form to the monomeric form is associated with a conformational change of the molecule and irreversible loss of catalytic activity Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.1.34 LPL
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
3.1.1.34 apolipoprotein CII important cofactor Homo sapiens