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Literature summary extracted from

  • Cherepanov, A.V.; Doroshenko, E.V.; Matysik, J.; de Vries, S.; de Groot, H.J.
    The associative nature of adenylyl transfer catalyzed by T4 DNA ligase (2008), Proc. Natl. Acad. Sci. USA, 105, 8563-8568.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.5.1.1 Mg2+ required for activity Tequatrovirus T4

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Tequatrovirus T4
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m in the first step of catalysis, DNA ligase binds ATP, forming a high-energy covalent enzyme-nucleotide complex. Nucleophilic attack on the alpha-phosphorus of ATP results in cleavage of the triphosphate moiety, formation of the enzyme-AMP epsilon-amino lysyl phosphoramidate, and release of the diphosphate Tequatrovirus T4 AMP + diphosphate + (deoxyribonucleotide)m+n
-
 r

Synonyms

EC Number Synonyms Comment Organism
6.5.1.1 T4 DNA ligase
-
 Tequatrovirus T4

Cofactor

EC Number Cofactor Comment Organism Structure
6.5.1.1 ATP
-
 Tequatrovirus T4