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Literature summary extracted from
- Recognition and repair of UV lesions in loop structures of duplex DNA by DASH-type cryptochrome (2008), Proc. Natl. Acad. Sci. USA, 105, 21023-21027.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.1.99.3 | - |
Arabidopsis thaliana |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 4.1.99.3 | crystallized in 85 mM Na-citrate, pH 4.6, 170 mM NH4- acetate, 21.5% (w/v) PEG 4000, and 15% (v/v) glycerol | Arabidopsis thaliana |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.1.99.3 | 64983 | - |
2 * 64983, X-ray crystallography | Arabidopsis thaliana |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.99.3 | Arabidopsis thaliana | Q84RJ5 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.1.99.3 | - |
Arabidopsis thaliana |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.99.3 | cyclobutadipyrimidine in DNA | the enzyme repairs specifically cyclobutane pyrimidine dimers in UV-damaged single-stranded DNA, the enzyme catalyzes light-driven DNA repair like conventional photolyases but lacks an efficient flipping mechanism for interaction with cyclobutane pyrimidine dimer lesions within duplex DNA | Arabidopsis thaliana | pyrimidine residues in DNA | - |
? |  |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.1.99.3 | homodimer | 2 * 64983, X-ray crystallography | Arabidopsis thaliana |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.99.3 | CPD photolyase | - |
Arabidopsis thaliana |
| 4.1.99.3 | cry3 | - |
Arabidopsis thaliana |
| 4.1.99.3 | cryptochrome 3 | DASH-type cryptochrome, the enzyme catalyzes light-driven DNA repair like conventional photolyases but lacks an efficient flipping mechanism for interaction with cyclobutane pyrimidine dimer lesions within duplex DNA | Arabidopsis thaliana |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.99.3 | 5,10-methenyltetrahydrofolate | - |
Arabidopsis thaliana | |
| 4.1.99.3 | FAD | - |
Arabidopsis thaliana | |
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Release 2023.1 (January 2023)
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