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Literature summary extracted from

  • Amaro, R.E.; Schnaufer, A.; Interthal, H.; Hol, W.; Stuart, K.D.; McCammon, J.A.
    Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma brucei (2008), Proc. Natl. Acad. Sci. USA, 105, 17278-17283.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.5.1.3 virtual screen of REL1 crystal structure for inhibitors Trypanosoma brucei

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.5.1.3 1-amino-4-(3-(aminosulfonyl)anilino)-9,10-dioxo-9,10-dihydro-2-anthracenesulfonic acid 68.5% residual activity at 0.01 mM, presence of Triton X-100. Molecular dynamics simulations Trypanosoma brucei
6.5.1.3 3-((4-(ethylamino)phenyl)diazenyl)-4,5-dihydroxy-2,7-naphthalenedisulfonic acid 4.1% residual activity at 0.01 mM, presence of Triton X-100. Molecular dynamics simulations Trypanosoma brucei
6.5.1.3 3-((5-chloro-2-hydroxyphenyl)diazenyl)-4,5-dihydroxy-2,7-naphthalenedisulfonic acid 8.6% residual activity at 0.01 mM, presence of Triton X-100. Molecular dynamics simulations Trypanosoma brucei
6.5.1.3 4,5-dihydroxy-3-(1-naphthyldiazenyl)-2,7-naphthalenedisulfonic acid 43.1% residual activity at 0.01 mM, presence of Triton X-100. Molecular dynamics simulations Trypanosoma brucei

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.3 Trypanosoma brucei P86927
-
-

Synonyms

EC Number Synonyms Comment Organism
6.5.1.3 REL1
-
 Trypanosoma brucei
6.5.1.3 RNA-editing ligase 1
-
 Trypanosoma brucei