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Literature summary extracted from

  • Nashev, L.G.; Chandsawangbhuwana, C.; Balazs, Z.; Atanasov, A.G.; Dick, B.; Frey, F.J.; Baker, M.E.; Odermatt, A.
    Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids (2007), PLoS ONE, 2, e561.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.146 expression in HEK-293 cell of 11beta-hydroxysteroid dehydrogenase alone or together with hexose-6-phosphate dehydrogenase Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.146 analysis of substratebinding by threedimensional modeling. There are favorable interactions between the C7-hydroxyl group of substrate and the catalytic site when the A ring of substrate is oriented towards the interior of the enzyme Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 7-ketodehydroepiandrosterone + 2 NADPH + 2 H+
-
 Homo sapiens 7alpha-hydroxydehydroepiandrosterone + 7beta-hydroxydehydroepiandrosterone + 2 NADP+ formation of alpha- and beta-product in almost equal amounts. In presence of hexose-6-phosphate dehydrogenase, the 7keto-substrate is almost fully metabolized and the 7beta-product is preferentially formed ?
1.1.1.146 7alpha-hydroxydehydroepiandrosterone + NADP+
-
 Homo sapiens 7beta-hydroxydehydroepiandrosterone + 7-ketodehydroepiandrosterone + NADPH in presence of hexose-6-phosphate dehydrogenase, less substrate is metabolized and accumulation of 7-ketodehydroepiandrosterone is abolished ?
1.1.1.146 7beta-hydroxydehydroepiandrosterone + NADP+
-
 Homo sapiens 7alpha-hydroxydehydroepiandrosterone + 7-ketodehydroepiandrosterone + NADPH formation of products in almost equal amounts. In presence of hexose-6-phosphate dehydrogenase, less substrate is metabolized and accumulation of 7-ketodehydroepiandrosterone is abolished ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.146 NADP+
-
 Homo sapiens
1.1.1.146 NADPH
-
 Homo sapiens