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Literature summary extracted from

  • Maia, A.; Schmitz-Afonso, I.; Martin, M.T.; Awang, K.; Laprevote, O.; Gueritte, F.; Litaudon, M.
    Acylphenols from Myristica crassa as new acetylcholinesterase inhibitors (2008), Planta Med., 74, 1457-1462.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 giganteone C isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry Electrophorus electricus
3.1.1.7 maingayone B isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry Electrophorus electricus
3.1.1.7 maingayone C isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry Electrophorus electricus
3.1.1.7 malabaricone A isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry Electrophorus electricus
3.1.1.7 malabaricone B isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry Electrophorus electricus
3.1.1.7 malabaricone C isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry Electrophorus electricus
3.1.1.7 promalabaricone B
-
 Electrophorus electricus
3.1.1.7 promalabaricone C
-
 Electrophorus electricus
3.1.1.7 tacrine
-
 Electrophorus electricus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Electrophorus electricus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 S-acetylthiocholine iodide + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Electrophorus electricus acetate + thiocholine iodide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 AChE
-
 Electrophorus electricus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.7 25
-
 assay at Electrophorus electricus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.7 8
-
 assay at Electrophorus electricus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.7 0.0094
-
-
 Electrophorus electricus malabaricone B
3.1.1.7 0.011
-
-
 Electrophorus electricus malabaricone A
3.1.1.7 0.0117
-
-
 Electrophorus electricus malabaricone C
3.1.1.7 0.07
-
 above Electrophorus electricus giganteone C
3.1.1.7 0.07
-
 above Electrophorus electricus maingayone B
3.1.1.7 0.07
-
 above Electrophorus electricus maingayone C
3.1.1.7 0.07
-
 above Electrophorus electricus giganteone A
3.1.1.7 0.115
-
-
 Electrophorus electricus tacrine
3.1.1.7 0.14
-
 above Electrophorus electricus promalabaricone B
3.1.1.7 0.14
-
 above Electrophorus electricus promalabaricone C