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Literature summary extracted from

  • Tansakul, P.; De-Eknamkul, W.
    Geranylgeraniol-18-hydroxylase: the last enzyme in the plaunotol biosynthetic pathway in Croton sublyratus (1998), Phytochemistry, 47, 1241-1246.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.146 geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2 Croton sublyratus this enzyme is involved in the final step of the biosynthetic pathway of plaunotol, an antipeptic ulcer constituent accumulated in this plant 18-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.146 Croton sublyratus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.146 leaf
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 Croton sublyratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.146 geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2
-
 Croton sublyratus 18-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.146 geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2 this enzyme is involved in the final step of the biosynthetic pathway of plaunotol, an antipeptic ulcer constituent accumulated in this plant Croton sublyratus 18-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.146 geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2 NADH shows about 70% of the activity with NADPH Croton sublyratus 18-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.146 geranylgeraniol-18-hydroxylase
-
 Croton sublyratus
1.14.14.146 GGOH-18-hydroxylase
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 Croton sublyratus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.14.14.146 100
-
 activity in the heated cell-free extract increases steadily during the first 30 min of the treatment. Thereafter, the enzyme activity declines rapidly and is almost undetectable after 60 min Croton sublyratus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.14.146 5
-
 assay at Croton sublyratus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.14.14.146 additional information
-
 above and below the pH optimum (pH 5) activity declines rapidly and is undetectable after 60 min Croton sublyratus