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Literature summary extracted from

  • Racay, P.; Tatarkova, Z.; Drgova, A.; Kaplan, P.; Dobrota, D.
    Ischemia-reperfusion induces inhibition of mitochondrial protein synthesis and cytochrome C oxidase activity in rat hippocampus (2008), Physiol. Res., 58, 127-138.
    View publication on PubMed

Application

EC Number Application Comment Organism
7.1.1.9 additional information inhibition of COX activity is rather caused by ischemia-induced modification of COX polypeptides than by inhibition of mitochondrial translation Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.9 additional information 15 min of global ischemia leads to the inhibition of COXI synthesis to 56% of control. After 1, 3 and 24 hours of reperfusion, COXI synthesis is inhibited to 46, 50 and 72% of control, respectively. Extent COXIII and COXII/ATPase6 synthesis inhibition is comparable to the extent of COXI synthesis inhibition. No significant changes in COXI mRNA and in both COXI and COXII protein level after ischemia, thus ischemia-reperfusion affects directly mitochondrial translation machinery. Ischemia in duration of 15 min and consequent 1, 3 and 24 hours of reperfusion leads to the inhibition of COX activity to 90.3, 80.3, 81.9 and 83.5% of control, respectively Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.9 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.9 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.9 brain
-
 Rattus norvegicus
-
7.1.1.9 hippocampus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.9 reduced cytochrome c + O2 + H+
-
 Rattus norvegicus oxidized cytochrome c + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.9 COX
-
 Rattus norvegicus
7.1.1.9 COX subunit I
-
 Rattus norvegicus
7.1.1.9 COXI
-
 Rattus norvegicus
7.1.1.9 COXII
-
 Rattus norvegicus
7.1.1.9 COXIII
-
 Rattus norvegicus
7.1.1.9 cytochrome c oxidase
-
 Rattus norvegicus