Literature summary extracted from

Fallarero, A.; Oinonen, P.; Gupta, S.; Blom, P.; Galkin, A.; Mohan, C.G.; Vuorela, P.M.
Inhibition of acetylcholinesterase by coumarins: the case of coumarin 106 (2008), Pharmacol. Res., 58, 215-221.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.1.7	coumarin 106	exhibits mixed-type AChE inhibition, targets a primary binding site at the active gorge and a secondary peripheral anionic binding site. Analysis of inhibitor binding, overview	Electrophorus electricus
3.1.1.7	galanthamine	-	Electrophorus electricus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.1.7	Electrophorus electricus	-	type VI-S AChE	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.1.1.7	AChE	-	Electrophorus electricus
3.1.1.7	type VI-S AChE	-	Electrophorus electricus

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
3.1.1.7	25	-	assay at	Electrophorus electricus

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
3.1.1.7	8	-	assay at	Electrophorus electricus

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
3.1.1.7	0.00236	-	coumarin 106	-	Electrophorus electricus

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
3.1.1.7	0.00497	-	-	Electrophorus electricus	coumarin 106

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Release 2023.1 (January 2023)