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Literature summary extracted from

  • Chai, Y.; Lin, Y.F.
    Dual regulation of the ATP-sensitive potassium channel by activation of cGMP-dependent protein kinase (2008), Pflugers Arch., 456, 897-915.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.12 8-bromo-cGMP
-
 Homo sapiens

Application

EC Number Application Comment Organism
2.7.11.12 medicine PKG exerts dual functional regulation of neuronal ATP-sensitive potassium channels in a sulfonylurea receptor subunit-dependent manner, which may provide new means of therapeutic intervention for manipulating neuronal excitability and/or survival Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.12 KT5823
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.12 HEK-293 cell
-
 Homo sapiens
-
2.7.11.12 SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.12 ATP + Kemptide
-
 Homo sapiens ADP + Kemptide phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.12 PKG
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.12 ATP
-
 Homo sapiens
2.7.11.12 cGMP dependent Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.12 0.00023
-
-
 Homo sapiens KT5823