BRENDA - Enzyme Database

The Wolbachia endosymbiont of Brugia malayi has an active phosphoglycerate mutase: a candidate target for anti-filarial therapies

Foster, J.M.; Raverdy, S.; Ganatra, M.B.; Colussi, P.A.; Taron, C.H.; Carlow, C.K.; Parasitol. Res. 104, 1047-1052 (2009)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
5.4.2.12
medicine
drug target for novel anti-filarial therapies that selectively target the Wolbachia endosymbiont of Brugia malayi
Wolbachia sp.
Cloned(Commentary)
EC Number
Commentary
Organism
5.4.2.12
expressed in Escherichia coli (inactive unsoluble protein) and Kluyveromyces lactis (active enzyme)
Wolbachia sp.
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
5.4.2.12
56000
-
deduced from sequence of cDNA
Wolbachia sp.
5.4.2.12
100000
-
around 100000 Da, SDS-PAGE, enzyme fused with N-terminal maltose binding protein
Wolbachia sp.
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.4.2.12
Wolbachia sp.
Q5GSN3
-
-
Purification (Commentary)
EC Number
Commentary
Organism
5.4.2.12
amylose column chromatography
Wolbachia sp.
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.4.2.12
2-phospho-D-glycerate
-
694538
Wolbachia sp.
3-phospho-D-glycerate
-
-
-
r
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
5.4.2.12
additional information
cofactor-independent
Wolbachia sp.
Application (protein specific)
EC Number
Application
Commentary
Organism
5.4.2.12
medicine
drug target for novel anti-filarial therapies that selectively target the Wolbachia endosymbiont of Brugia malayi
Wolbachia sp.
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
5.4.2.12
expressed in Escherichia coli (inactive unsoluble protein) and Kluyveromyces lactis (active enzyme)
Wolbachia sp.
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
5.4.2.12
additional information
cofactor-independent
Wolbachia sp.
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
5.4.2.12
56000
-
deduced from sequence of cDNA
Wolbachia sp.
5.4.2.12
100000
-
around 100000 Da, SDS-PAGE, enzyme fused with N-terminal maltose binding protein
Wolbachia sp.
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
5.4.2.12
amylose column chromatography
Wolbachia sp.
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.4.2.12
2-phospho-D-glycerate
-
694538
Wolbachia sp.
3-phospho-D-glycerate
-
-
-
r