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Literature summary extracted from

  • Jones, C.; Anderson, S.; Singha, U.K.; Chaudhuri, M.
    Protein phosphatase 5 is required for Hsp90 function during proteotoxic stresses in Trypanosoma brucei (2008), Parasitol. Res., 102, 835-844.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.16 microcystin inhibits by binding tightly to the phosphatase catalytic domain of PP5 Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.16 cytosol under normal growth conditions, PP5 is primarily localized in the cytosol Trypanosoma brucei 5829
-
3.1.3.16 nucleus with increase in growth temperature (up to 40°C) and geldanamycin treatment, PP5 translocates to the nucleus Trypanosoma brucei 5634
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.16 Trypanosoma brucei
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.16 microcystin-Sepharose bead chromatography Trypanosoma brucei

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.16 phosphorylated Hsp90 + H2O PP5 positively regulates the function of Hsp90 to maintain cellular homeostasis during proteotoxic stresses Trypanosoma brucei Hsp90 + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.16 PP5
-
 Trypanosoma brucei
3.1.3.16 protein phosphatase 5
-
 Trypanosoma brucei