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Literature summary extracted from

  • Xu, X.H.; Trunkfield, A.E.; Bugg, T.D.; Qing, F.L.
    Synthesis of gem-difluorinated nucleoside analogues of the liposidomycins and evaluation as MraY inhibitors (2008), Org. Biomol. Chem., 6, 157-161.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.13 5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-3'-deoxy-3',3'-difluorouridine low inhibition (29% at 11.4 mM), analogue of a liposidomycin (potent and selective inhibitor) assembled from lactol and gem-difluoromethylenated nucleoside with 1,2-trans-beta-furanoside linkage Micrococcus flavus

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.13 Micrococcus flavus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.8.13 solubilization from membrane preparation through shaking for 30 min at 4°C at pH 7.5 and in presence of 1 mM MgCl2 and 2 mM beta-mercaptoethanol Micrococcus flavus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.13 UDP-MurNAc-pentapeptide + undecaprenyl phosphate 30 min, 35°C, pH 7.5 Micrococcus flavus UMP + undecaprenol diphosphate N-acetylmuramyl pentapeptide
-
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Synonyms

EC Number Synonyms Comment Organism
2.7.8.13 MraY
-
Micrococcus flavus
2.7.8.13 phospho-MurNAc-pentapeptide translocase
-
Micrococcus flavus