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Literature summary extracted from

  • Joachims, M.L.; Marble, P.; Knott-Craig, C.; Pastuszko, P.; Blackburn, M.R.; Thompson, L.F.
    Inhibition of deoxynucleoside kinases in human thymocytes prevents dATP accumulation and induction of apoptosis (2008), Nucleosides Nucleotides Nucleic Acids, 27, 816-820.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.1.74 medicine thymocytes lacking adenosine deaminase activity accumulate intracellular dATP and undergo apoptosis. Inhibition of deoxycytidine kinase prevents the accumulation of dATP and induction of apoptosis to a large degree, inhibition of both deoxycytidine kinase and adenosine kinase completely abrogates accumulation of dATP and significantly reduces the induction of apoptosis Homo sapiens
2.7.1.76 medicine thymocytes lacking adenosine deaminase activity accumulate intracellular dATP and undergo apoptosis. Inhibition of both deoxycytidine kinase and adenosine kinase completely abrogates accumulation of dATP and significantly reduces the induction of apoptosis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.74 2'-deoxycytidine
-
 Homo sapiens
2.7.1.76 5'-amino-5'-deoxyadenosine
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens
-
-
-
2.7.1.76 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.74 thymocyte
-
 Homo sapiens
-
2.7.1.74 thymocyte suspension culture Homo sapiens
-
2.7.1.76 thymocyte suspension culture Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.74 dCK
-
 Homo sapiens
2.7.1.74 deoxycytidine kinase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.74 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.74 malfunction dCK inhibition reduces the induction of apoptosis in thymocytes Homo sapiens