BRENDA - Enzyme Database show

Inhibition of deoxynucleoside kinases in human thymocytes prevents dATP accumulation and induction of apoptosis

Joachims, M.L.; Marble, P.; Knott-Craig, C.; Pastuszko, P.; Blackburn, M.R.; Thompson, L.F.; Nucleosides Nucleotides Nucleic Acids 27, 816-820 (2008)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
2.7.1.74
medicine
thymocytes lacking adenosine deaminase activity accumulate intracellular dATP and undergo apoptosis. Inhibition of deoxycytidine kinase prevents the accumulation of dATP and induction of apoptosis to a large degree, inhibition of both deoxycytidine kinase and adenosine kinase completely abrogates accumulation of dATP and significantly reduces the induction of apoptosis
Homo sapiens
2.7.1.76
medicine
thymocytes lacking adenosine deaminase activity accumulate intracellular dATP and undergo apoptosis. Inhibition of both deoxycytidine kinase and adenosine kinase completely abrogates accumulation of dATP and significantly reduces the induction of apoptosis
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.74
2'-deoxycytidine
-
Homo sapiens
2.7.1.76
5'-amino-5'-deoxyadenosine
-
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.74
Homo sapiens
-
-
-
2.7.1.76
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
thymocyte
; suspension culture
Homo sapiens
-
2.7.1.76
thymocyte
suspension culture
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
694483
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Homo sapiens
Application (protein specific)
EC Number
Application
Commentary
Organism
2.7.1.74
medicine
thymocytes lacking adenosine deaminase activity accumulate intracellular dATP and undergo apoptosis. Inhibition of deoxycytidine kinase prevents the accumulation of dATP and induction of apoptosis to a large degree, inhibition of both deoxycytidine kinase and adenosine kinase completely abrogates accumulation of dATP and significantly reduces the induction of apoptosis
Homo sapiens
2.7.1.76
medicine
thymocytes lacking adenosine deaminase activity accumulate intracellular dATP and undergo apoptosis. Inhibition of both deoxycytidine kinase and adenosine kinase completely abrogates accumulation of dATP and significantly reduces the induction of apoptosis
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.74
2'-deoxycytidine
-
Homo sapiens
2.7.1.76
5'-amino-5'-deoxyadenosine
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
thymocyte
; suspension culture
Homo sapiens
-
2.7.1.76
thymocyte
suspension culture
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
694483
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
2.7.1.74
malfunction
dCK inhibition reduces the induction of apoptosis in thymocytes
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
2.7.1.74
malfunction
dCK inhibition reduces the induction of apoptosis in thymocytes
Homo sapiens