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Literature summary extracted from
- Inhibition of orotidine-5-monophosphate decarboxylase--discoveries and lessons (2008), Nucleic Acids Symp. Ser., 52, 85-86.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.23 | 6-aminouridine 5'-monophosphate | - |
Homo sapiens |  |
| 4.1.1.23 | 6-aminouridine 5'-monophosphate | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | 6-aminouridine 5'-monophosphate | - |
Plasmodium falciparum | |
| 4.1.1.23 | 6-aminouridine 5'-monophosphate | - |
Staphylococcus aureus | |
| 4.1.1.23 | 6-azidouridine 5'-monophosphate | - |
Homo sapiens | |
| 4.1.1.23 | 6-azidouridine 5'-monophosphate | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | 6-azidouridine 5'-monophosphate | - |
Plasmodium falciparum | |
| 4.1.1.23 | 6-azidouridine 5'-monophosphate | - |
Staphylococcus aureus | |
| 4.1.1.23 | 6-cyanouridine 5'-monophosphate | - |
Homo sapiens | |
| 4.1.1.23 | 6-cyanouridine 5'-monophosphate | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | 6-cyanouridine 5'-monophosphate | - |
Plasmodium falciparum | |
| 4.1.1.23 | 6-cyanouridine 5'-monophosphate | - |
Staphylococcus aureus | |
| 4.1.1.23 | 6-iodouridine 5'-monophosphate | - |
Helicobacter pylori | |
| 4.1.1.23 | 6-iodouridine 5'-monophosphate | - |
Homo sapiens | |
| 4.1.1.23 | 6-iodouridine 5'-monophosphate | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | 6-iodouridine 5'-monophosphate | - |
Plasmodium falciparum | |
| 4.1.1.23 | 6-iodouridine 5'-monophosphate | - |
Staphylococcus aureus | |
| 4.1.1.23 | 6-methyl-uridine | - |
Plasmodium falciparum | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.23 | Orotidine 5'-phosphate | Staphylococcus aureus | - |
UMP + CO2 | - |
? | |
| 4.1.1.23 | Orotidine 5'-phosphate | Homo sapiens | - |
UMP + CO2 | - |
? | |
| 4.1.1.23 | Orotidine 5'-phosphate | Helicobacter pylori | - |
UMP + CO2 | - |
? | |
| 4.1.1.23 | Orotidine 5'-phosphate | Plasmodium falciparum | - |
UMP + CO2 | - |
? | |
| 4.1.1.23 | Orotidine 5'-phosphate | Methanothermobacter thermautotrophicus | - |
UMP + CO2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.23 | Helicobacter pylori | - |
- |
- |
| 4.1.1.23 | Homo sapiens | - |
- |
- |
| 4.1.1.23 | Methanothermobacter thermautotrophicus | O26232 | - |
- |
| 4.1.1.23 | Plasmodium falciparum | - |
- |
- |
| 4.1.1.23 | Staphylococcus aureus | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.23 | 6-cyanouridine 5'-monophosphate | pseudohydrolysis process | Staphylococcus aureus | 6-hydroxyuridine 5'-monophosphate + CN- | - |
? | |
| 4.1.1.23 | 6-cyanouridine 5'-monophosphate | pseudohydrolysis process | Homo sapiens | 6-hydroxyuridine 5'-monophosphate + CN- | - |
? | |
| 4.1.1.23 | 6-cyanouridine 5'-monophosphate | pseudohydrolysis process | Plasmodium falciparum | 6-hydroxyuridine 5'-monophosphate + CN- | - |
? | |
| 4.1.1.23 | 6-cyanouridine 5'-monophosphate | pseudohydrolysis process | Methanothermobacter thermautotrophicus | 6-hydroxyuridine 5'-monophosphate + CN- | - |
? | |
| 4.1.1.23 | Orotidine 5'-phosphate | - |
Staphylococcus aureus | UMP + CO2 | - |
? | |
| 4.1.1.23 | Orotidine 5'-phosphate | - |
Homo sapiens | UMP + CO2 | - |
? | |
| 4.1.1.23 | Orotidine 5'-phosphate | - |
Helicobacter pylori | UMP + CO2 | - |
? | |
| 4.1.1.23 | Orotidine 5'-phosphate | - |
Plasmodium falciparum | UMP + CO2 | - |
? | |
| 4.1.1.23 | Orotidine 5'-phosphate | - |
Methanothermobacter thermautotrophicus | UMP + CO2 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.1.23 | ODCase | - |
Staphylococcus aureus |
| 4.1.1.23 | ODCase | - |
Homo sapiens |
| 4.1.1.23 | ODCase | - |
Helicobacter pylori |
| 4.1.1.23 | ODCase | - |
Plasmodium falciparum |
| 4.1.1.23 | ODCase | - |
Methanothermobacter thermautotrophicus |
| 4.1.1.23 | Orotidine-5'-monophosphate decarboxylase | - |
Staphylococcus aureus |
| 4.1.1.23 | Orotidine-5'-monophosphate decarboxylase | - |
Homo sapiens |
| 4.1.1.23 | Orotidine-5'-monophosphate decarboxylase | - |
Helicobacter pylori |
| 4.1.1.23 | Orotidine-5'-monophosphate decarboxylase | - |
Plasmodium falciparum |
| 4.1.1.23 | Orotidine-5'-monophosphate decarboxylase | - |
Methanothermobacter thermautotrophicus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.23 | 0.00019 | - |
6-azidouridine 5'-monophosphate | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | 0.00084 | - |
6-aminouridine 5'-monophosphate | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | 0.002 | - |
6-azidouridine 5'-monophosphate | - |
Plasmodium falciparum | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.23 | 0.0044 | - |
chloroquine-resistant strain | Plasmodium falciparum | 6-iodouridine 5'-monophosphate | |
| 4.1.1.23 | 0.0062 | - |
chloroquine-sensitive strain | Plasmodium falciparum | 6-iodouridine 5'-monophosphate | |
| 4.1.1.23 | 0.5305 | - |
- |
Plasmodium falciparum | 6-methyl-uridine | |
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