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Literature summary extracted from

  • Clausen, A.R.; Girandon, L.; Knecht, W.; Survery, S.; Andreasson, E.; Munch-Petersen, B.; Piskur, J.
    A multisubstrate deoxyribonucleoside kinase from plants (2008), Nucleic Acids Symp. Ser., 52, 489-490.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.145 upon expression in Escherichia coli, enzyme sensitizes cells against various nucleic acid analogs such as gemcitabine Arabidopsis thaliana

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.145 Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.145 2'-deoxyadenosine + ATP specificity constant 33000 per s and M Arabidopsis thaliana 2'-deoxyadenosine 5'-phosphate + ADP
-
 ?
2.7.1.145 2'-deoxycytidine + ATP specificity constant 18000 per s and M Arabidopsis thaliana 2'-deoxycytidine 5'-phosphate + ADP
-
 ?
2.7.1.145 2'-deoxyguanosine + ATP specificity constant 10000 per s and M Arabidopsis thaliana 2'-deoxyguanosine 5'-phosphate + ADP
-
 ?
2.7.1.145 2'-deoxyuridine + ATP specificity constant 410 per s and M Arabidopsis thaliana 2'-deoxyuridine 5'-phosphate + ADP
-
 ?
2.7.1.145 bromovinyldeoxyuridine + ATP specificity constant 930 per s and M Arabidopsis thaliana bromovinyldeoxyuridine 5'-phosphate + ADP
-
 ?
2.7.1.145 difluorodeoxycytidine + ATP i.e. gemcitabine. Efficient in vivo phosphorylation, specificity constant 4800 per s and M Arabidopsis thaliana difluorodeoxycytidine 5'-phosphate + ADP
-
 ?
2.7.1.145 additional information no substrate: deoxythymidine Arabidopsis thaliana ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.145 AGCK
-
 Arabidopsis thaliana