Literature summary extracted from

Takagi, K.; Okuda-Ashitaka, E.; Mabuchi, T.; Katano, T.; Ohnishi, T.; Matsumura, S.; Ohnaka, M.; Kaneko, S.; Abe, T.; Hirata, T.; Fujiwara, S.; Minami, T.; Ito, S.
Involvement of stem cell factor and its receptor tyrosine kinase c-kit in pain regulation (2008), Neuroscience, 153, 1278-1288.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.7.10.1	capsaicin	c-kit receptor expression is significantly up-regulated in medium-sized dorsal root ganglia neurons after neonatal capsaicin treatment	Mus musculus

Application

EC Number	Application	Comment	Organism
2.7.10.1	medicine	c-kit receptor is mainly expressed in peptidergic small-sized dorsal root ganglia neurons and may be involved in pain regulation both peripherally and centrally	Mus musculus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.7.10.1	additional information	selective elimination of unmyelinated C-fibers by neonatal capsaicin treatment results in marked reduction of the c-kit receptor and calcitonin gene-related peptide expression in the superficial layer of the spinal cord. C-kit receptor expression is significantly down-regulated in medium-sized dorsal root ganglia neurons after nerve injury	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.10.1	Mus musculus	-	male ddY mice	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.10.1	neuron	expressed in small- and medium sized dorsal root ganglia neurons, c-kit receptor is co-expressed in 58.4% of calcitonin gene-related peptide-positive, but only 5.1% of isolectin B4-positive, dorsal root ganglia neurons	Mus musculus	-
2.7.10.1	spinal cord	in the superficial layer of the dorsal horn and co-localized with calcitonin gene-related peptide in central terminals of peptidergic small-sized dorsal root ganglia neurons	Mus musculus	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.10.1	c-kit receptor	-	Mus musculus
2.7.10.1	c-Kit receptor tyrosine kinase	-	Mus musculus

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Release 2023.1 (January 2023)