Literature summary extracted from

Vibert, Y.M.; Ashraf, Q.M.; Mishra, O.P.; Delivoria-Papadopoulos, M.
Mechanism of Ca2+-influx and Ca2+/calmodulin-dependent protein kinase IV activity during in utero hypoxia in cerebral cortical neuronal nuclei of the guinea pig fetus at term (2008), Neurosci. Lett., 440, 227-231.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.7.11.17	additional information	hypoxia results in increased nuclear Ca2+-influx and increased CaM kinase IV activity	Cavia porcellus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.7.11.17	additional information	the administration of clonidine, an inhibitor of high-affinity nuclear Ca2+-ATPase, prevents the hypoxia-induced increase in nuclear Ca2+-influx and CaM kinase IV activity	Cavia porcellus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
2.7.11.17	Ca2+	dependent on	Cavia porcellus

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.11.17	Cavia porcellus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.11.17	cerebral cortex	cerebral cortical neuronal nucleus	Cavia porcellus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.11.17	ATP + cyclic AMP response element binding protein	phosphorylated at Ser133	Cavia porcellus	ADP + phosphorylated cyclic AMP response element binding protein	-	?
2.7.11.17	ATP + syntide-2	-	Cavia porcellus	ADP + phosphorylated syntide-2	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.11.17	calcium/calmodulin-dependent protein kinase IV	-	Cavia porcellus
2.7.11.17	CaMK IV	-	Cavia porcellus

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.7.11.17	ATP	-	Cavia porcellus
2.7.11.17	Calmodulin	dependent on	Cavia porcellus

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Release 2023.1 (January 2023)