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Literature summary extracted from

  • Dlaboga, D.; Hajjhussein, H.; ODonnell, J.M.
    Chronic haloperidol and clozapine produce different patterns of effects on phosphodiesterase-1B, -4B, and -10A expression in rat striatum (2008), Neuropharmacology, 54, 745-754.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.17 clozapine chronic treatment with 20 mg/kg clozapine increases PDE10A expression by 62% Rattus norvegicus
3.1.4.17 haloperidol chronic treatment with 1 mg/kg haloperidol increases PDE10A expression by 118% Rattus norvegicus
3.1.4.17 haloperidol chronic treatment with 1 mg/kg haloperidol increases PDE10A expression by 65% Rattus norvegicus
3.1.4.17 additional information not influenced by treatment with clozapine Rattus norvegicus
3.1.4.53 haloperidol chronic treatment with 20 mg/kg clozapine increases PDE4B2 and PDE4B4 expression by 102 and 71%, respectively Rattus norvegicus
3.1.4.53 additional information PDE4B1, PDE4B2, PDE4B3, and PDE4B4 are not changed by chronic haloperidol treatment Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.17 expressed in COS-1 cells Rattus norvegicus
3.1.4.53 expressed in COS-1 cells Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.17 cytosol PDE1B is found almost exclusively in the cytosolic fraction Rattus norvegicus 5829
-
3.1.4.17 membrane PDE10A is found almost exclusively in the membrane fraction Rattus norvegicus 16020
-
3.1.4.53 cytosol
-
Rattus norvegicus 5829
-
3.1.4.53 membrane
-
Rattus norvegicus 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.17 60000
-
SDS-PAGE Rattus norvegicus
3.1.4.17 74000
-
SDS-PAGE Rattus norvegicus
3.1.4.53 58000
-
PDE4B4 recombinant protein, SDS-PAGE Rattus norvegicus
3.1.4.53 69000
-
PDE4B2 recombinant protein, SDS-PAGE Rattus norvegicus
3.1.4.53 87000
-
PDE4B1 or PDE4B3 recombinant protein, SDS-PAGE, the 87000 Da band is termed PDE4B1/B3 due to difficulty of resolving it into separate bands using SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Rattus norvegicus
-
-
-
3.1.4.53 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.17 corpus striatum
-
Rattus norvegicus
-
3.1.4.53 corpus striatum
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.17 3',5'-cAMP + H2O
-
Rattus norvegicus 5'-AMP
-
?
3.1.4.17 3',5'-cGMP + H2O
-
Rattus norvegicus 5'-GMP
-
?
3.1.4.17 nucleoside 3',5'-cyclic phosphate + H2O
-
Rattus norvegicus nucleoside 5'-phosphate
-
?
3.1.4.53 3',5'-cAMP + H2O
-
Rattus norvegicus 5'-AMP
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.17 PDE10A
-
Rattus norvegicus
3.1.4.17 PDE1B
-
Rattus norvegicus
3.1.4.17 phosphodiesterase-10A
-
Rattus norvegicus
3.1.4.17 phosphodiesterase-1B
-
Rattus norvegicus
3.1.4.53 PDE4B
-
Rattus norvegicus
3.1.4.53 PDE4B1 isozyme Rattus norvegicus
3.1.4.53 PDE4B2 isozyme Rattus norvegicus
3.1.4.53 PDE4B3 isozyme Rattus norvegicus
3.1.4.53 PDE4B4 isozyme Rattus norvegicus
3.1.4.53 phosphodiesterase-4B
-
Rattus norvegicus