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Literature summary extracted from

  • Kruhlak, M.; Crouch, E.E.; Orlov, M.; Montano, C.; Gorski, S.A.; Nussenzweig, A.; Misteli, T.; Phair, R.D.; Casellas, R.
    The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks (2007), Nature, 447, 730-734.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.6 etoposide treatment with 0.02 mM etoposide leads to a transient inhibition of rRNA synthesis Mus musculus
2.7.7.6 additional information gamma irradiation leads to a transient inhibition of rRNA synthesis, but Pol I transcription is not blocked by DNA damage itself, but by the action of DNA repair enzymes Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.6 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.6 MEF cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.6 nucleoside triphosphate + RNAn
-
 Mus musculus diphosphate + RNAn+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.6 Pol I
-
 Mus musculus
2.7.7.6 RNA polymerase I
-
 Mus musculus