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Literature summary extracted from

  • Martinez-Fleites, C.; Macauley, M.S.; He, Y.; Shen, D.L.; Vocadlo, D.J.; Davies, G.J.
    Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation (2008), Nat. Struct. Mol. Biol., 15, 764-765.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.1.255
-
 Xanthomonas campestris

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.255 D925A active site mutant Homo sapiens
2.4.1.255 H558A active site mutant Homo sapiens
2.4.1.255 H558D active site mutant Homo sapiens
2.4.1.255 H558E active site mutant Homo sapiens
2.4.1.255 H901Y active site mutant Homo sapiens
2.4.1.255 H920A active site mutant, deleterious Homo sapiens
2.4.1.255 K842A active site mutant, low specific activity Homo sapiens
2.4.1.255 K898A active site mutant, Lys898, which is involved in uracil binding, mutation results in a protein with no apparent activity Homo sapiens
2.4.1.255 Q839E active site mutant Homo sapiens
2.4.1.255 Q839N active site mutant, low specific activity Homo sapiens
2.4.1.255 T921A active site mutant, 18% activity compared to wild-type Homo sapiens
2.4.1.255 Y841A active site mutant, lowers specific activity to 24% compared to wild-type Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.255 UDP inhibits by excess Xanthomonas campestris

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.255 additional information Homo sapiens enzyme catalyzes O-GlcNAc addition ?
-
 ?
2.4.1.255 additional information Xanthomonas campestris enzyme catalyzes O-GlcNAc addition ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.255 Homo sapiens
-
-
-
2.4.1.255 Xanthomonas campestris
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.255 additional information enzyme catalyzes O-GlcNAc addition Homo sapiens ?
-
 ?
2.4.1.255 additional information enzyme catalyzes O-GlcNAc addition Xanthomonas campestris ?
-
 ?
2.4.1.255 UDP-N-acetyl-D-glucosamine + [protein]-L-serine
-
 Xanthomonas campestris UDP + [protein]-O3-(N-acetyl-D-glucosaminyl)-L-serine
-
 ?
2.4.1.255 UDP-N-acetyl-D-glucosamine + [protein]-L-threonine
-
 Xanthomonas campestris UDP + [protein]-O3-(N-acetyl-D-glucosaminyl)-L-threonine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.255 glycosyltransferase OGT
-
 Homo sapiens
2.4.1.255 glycosyltransferase OGT
-
 Xanthomonas campestris
2.4.1.255 HsOGT
-
 Homo sapiens
2.4.1.255 human OGT
-
 Homo sapiens
2.4.1.255 O-GlcNAc transferase
-
 Homo sapiens
2.4.1.255 O-GlcNAc transferase
-
 Xanthomonas campestris
2.4.1.255 OGT
-
 Homo sapiens
2.4.1.255 OGT
-
 Xanthomonas campestris
2.4.1.255 UDP-GlcNAc:polypeptidyl transferase
-
 Homo sapiens
2.4.1.255 UDP-GlcNAc:polypeptidyl transferase
-
 Xanthomonas campestris
2.4.1.255 XcOGT
-
 Xanthomonas campestris