Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kwon, Y.K.; Lu, W.; Melamud, E.; Khanam, N.; Bognar, A.; Rabinowitz, J.D.
    A domino effect in antifolate drug action in Escherichia coli (2008), Nat. Chem. Biol., 4, 602-608.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.17 dihydrofolate treatment of cells with trimethoprim leads to inhibition due to accumulation of dihydrofolate through the inhibition of dihydrofolate reductase. Therefore falling dihydrofolate reductase activity leads to falling folylpolyglutamate synthase activity in a domino-like cascade Escherichia coli
6.3.2.17 trimethoprim treatment of cells leads to inhibition due to accumulation of dihydrofolate through the inhibition of dihydrofolate reductase. Therefore falling dihydrofolate reductase activity leads to falling folylpolyglutamate synthase activity in a domino-like cascade Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.17 Escherichia coli
-
-
-