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Literature summary extracted from

  • Graf, C.; Klumpp, M.; Habig, M.; Rovina, P.; Billich, A.; Baumruker, T.; Oberhauser, B.; Bornancin, F.
    Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor (2008), Mol. Pharmacol., 74, 925-932.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.138 expression in baculovirus-infected Sf9, overexpression in COS1-CerK cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.138 adamantane-1-carboxylic acid (2-benzoylamino-benzothiazol-6-yl)amide NVP-231, a potent, specific, and reversible CerK inhibitor that competitively inhibits binding of ceramide to CerK Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.138 ceramide + ATP Homo sapiens key enzyme for controlling ceramide levels ceramide 1-phosphate + ADP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.138 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.138 neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.138 ceramide + ATP
-
 Homo sapiens ceramide 1-phosphate + ADP
-
 ?
2.7.1.138 ceramide + ATP key enzyme for controlling ceramide levels Homo sapiens ceramide 1-phosphate + ADP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.138 CERK
-
 Homo sapiens
2.7.1.138 hCERK
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.138 0.000012
-
-
 Homo sapiens adamantane-1-carboxylic acid (2-benzoylamino-benzothiazol-6-yl)amide