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Literature summary extracted from

  • Kaivosaari, S.; Toivonen, P.; Hesse, L.M.; Koskinen, M.; Court, M.H.; Finel, M.
    Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10 (2007), Mol. Pharmacol., 72, 761-768.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 expression of isozyme UGT1A4 in Spodoptera frugiperda Sf9 cell microsomal membranes, expression analysis, overview Homo sapiens
2.4.1.17 expression of isozyme UGT2B10 in Spodoptera frugiperda Sf9 cell microsomal membranes, expression analysis, overview Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 additional information
-
 additional information isozyme UGT1A4 with substrates nicotine and cotinine in liver and intestine microsomes Homo sapiens
2.4.1.17 additional information
-
 additional information isozyme UGT2B10 with substrates nicotine and cotinine in liver and intestine microsomes Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.17 UDP-D-glucuronate + acceptor Homo sapiens
-
 UDP + acceptor beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + cotinine Homo sapiens isozyme UGT2B10, cotinine is exclusively glucuronized in liver, no activity in intestinal microsomes UDP + ?
-
 ?
2.4.1.17 UDP-D-glucuronate + nicotine Homo sapiens isozyme UGT2B10, nicotine is mainly glucuronized in liver, very low activity in intestinal microsomes UDP + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens P22310 isozyme UGT1A4; isozyme UGT1A4
-
2.4.1.17 Homo sapiens P36537 isozyme UGT2B10; isozyme UGT2B10
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
 Homo sapiens
-
2.4.1.17 liver isozyme UGT2B10 is exclusively expressed in liver Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 UDP-D-glucuronate + acceptor
-
 Homo sapiens UDP + acceptor beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + cotinine isozyme UGT1A4 Homo sapiens UDP + ?
-
 ?
2.4.1.17 UDP-D-glucuronate + cotinine isozyme UGT2B10, cotinine is exclusively glucuronized in liver, no activity in intestinal microsomes Homo sapiens UDP + ?
-
 ?
2.4.1.17 UDP-D-glucuronate + cotinine isozyme UGT2B10 Homo sapiens UDP + ?
-
 ?
2.4.1.17 UDP-D-glucuronate + nicotine isozyme UGT1A4 Homo sapiens UDP + ?
-
 ?
2.4.1.17 UDP-D-glucuronate + nicotine isozyme UGT2B10, nicotine is mainly glucuronized in liver, very low activity in intestinal microsomes Homo sapiens UDP + ?
-
 ?
2.4.1.17 UDP-D-glucuronate + nicotine isozyme UGT2B10 Homo sapiens UDP + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase
-
 Homo sapiens
2.4.1.17 UGT1A4
-
 Homo sapiens
2.4.1.17 UGT2B10
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.17 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 7.4
-
 assay at Homo sapiens