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Literature summary extracted from
- Glutamate regulates the activity of topoisomerase I in mouse cerebellum (2008), Mol. Neurobiol., 38, 242-252.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.6.2.1 | gamma-aminobutyric acid | GABA, regulates the activity of topo I in mouse cerebellum sections, slightly and transiently inhibits topo I activity | Mus musculus |  |
| 5.6.2.1 | glutamate | regulates the activity of topo I in mouse cerebellum sections. Exhibits a significant time-dependent inhibition of topo I activity but no effect of the enzyme protein level | Mus musculus | |
| 5.6.2.1 | additional information | PARP inhibitors prevent the glutamate, but not GABA, induced decrease in topo I activity | Mus musculus | |
| 5.6.2.1 | topotecan | - |
Mus musculus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 5.6.2.1 | cytoplasm | - |
Mus musculus | 5737 | - |
| 5.6.2.1 | nucleus | - |
Mus musculus | 5634 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.6.2.1 | Ca2+ | inhibitory effect of glutamate is mediated by Ca2+ | Mus musculus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.6.2.1 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.6.2.1 | cerebellum | various regions of mouse brain | Mus musculus | - |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.6.2.1 | Topo I | - |
Mus musculus |
| 5.6.2.1 | Topoisomerase I | - |
Mus musculus |
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Release 2023.1 (January 2023)
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