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Literature summary extracted from

  • Gray, M.J.; Tavares, N.K.; Escalante-Semerena, J.C.
    The genome of Rhodobacter sphaeroides strain 2.4.1 encodes functional cobinamide salvaging systems of archaeal and bacterial origins (2008), Mol. Microbiol., 70, 824-836.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.62 into the vector pBAD24 for expression in serovar Typhimurium strain JE8268 Cereibacter sphaeroides
3.5.1.90 into the plasmid pBAD24 Pyrococcus furiosus
3.5.1.90 into the plasmid pBAD24 Streptomyces coelicolor
3.5.1.90 into the plasmid pBAD24 Rhodospirillum rubrum
3.5.1.90 into the plasmid pBAD24 Methanocaldococcus jannaschii
3.5.1.90 into the plasmid pBAD24 Methanosarcina mazei
3.5.1.90 into the plasmid pBAD24 Halalkalibacterium halodurans
3.5.1.90 into the plasmid pBAD24 Dehalococcoides mccartyi
3.5.1.90 into the plasmid pBAD24 Aeropyrum pernix
3.5.1.90 into the plasmid pBAD24 Ferroplasma acidarmanus
3.5.1.90 into the plasmid pBAD24 Cereibacter sphaeroides 2.4.1

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.62 GTP + adenosylcobinamide phosphate Cereibacter sphaeroides
-
 diphosphate + adenosylcobinamide-GDP
-
 ?
3.5.1.90 adenosylcobinamide + H2O Pyrococcus furiosus
-
 adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
3.5.1.90 adenosylcobinamide + H2O Streptomyces coelicolor
-
 adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
3.5.1.90 adenosylcobinamide + H2O Rhodospirillum rubrum
-
 adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
3.5.1.90 adenosylcobinamide + H2O Methanocaldococcus jannaschii
-
 adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
3.5.1.90 adenosylcobinamide + H2O Methanosarcina mazei
-
 adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
3.5.1.90 adenosylcobinamide + H2O Halalkalibacterium halodurans
-
 adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
3.5.1.90 adenosylcobinamide + H2O Dehalococcoides mccartyi
-
 adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
3.5.1.90 adenosylcobinamide + H2O Aeropyrum pernix
-
 adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
3.5.1.90 adenosylcobinamide + H2O Ferroplasma acidarmanus
-
 adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
3.5.1.90 adenosylcobinamide + H2O Cereibacter sphaeroides 2.4.1
-
 adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
6.3.1.10 ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate Cereibacter sphaeroides the enzyme is involved in the cobinamide salvaging pathways in bacteria and archaea, phylogenetic correlation, overview ADP + phosphate + adenosylcobinamide phosphate
-
 ?
6.3.1.10 ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate Halobacterium sp. the enzyme is involved in the cobinamide salvaging pathways in bacteria and archaea, phylogenetic correlation, overview ADP + phosphate + adenosylcobinamide phosphate
-
 ?
6.3.1.10 ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate Methanosarcina mazei the enzyme is involved in the the cobinamide salvaging pathways in bacteria and archaea, phylogenetic correlation, overview ADP + phosphate + adenosylcobinamide phosphate
-
 ?
6.3.1.10 ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate Salmonella enterica the enzyme is involved in the the cobinamide salvaging pathways in bacteria and archaea, Salmonella enterica serovar Typhimurium is unable to salvage cobinamide due to a lack of CbiZ, AdoCbi amidohydrolase, phylogenetic correlation, overview ADP + phosphate + adenosylcobinamide phosphate
-
 ?
6.3.1.10 ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate Halobacterium sp. NRC-1 the enzyme is involved in the cobinamide salvaging pathways in bacteria and archaea, phylogenetic correlation, overview ADP + phosphate + adenosylcobinamide phosphate
-
 ?
6.3.1.10 additional information Cereibacter sphaeroides inactivation of cobD, encoding threonine-phosphate decarboxylase, EC 4.1.1.81, prevents salvaging of Cbi, because AdoCby is not converted to AdoCbi-P in the absence of aminopropanolphosphate, but addition of 1-amino-2-propanol to the medium can reverse the effect ?
-
 ?
6.3.1.10 additional information Methanosarcina mazei inactivation of cobD, encoding threonine-phosphate decarboxylase, EC 4.1.1.81, prevents salvaging of Cbi, because AdoCby is not converted to AdoCbi-P in the absence of aminopropanolphosphate, but addition of 1-amino-2-propanol to the medium can reverse the effect ?
-
 ?
6.3.1.10 additional information Halobacterium sp. inactivation of cobD, encoding threonine-phosphate decarboxylase, EC 4.1.1.81, prevents salvaging of Cbi, because AdoCby is not converted to AdoCbi-P in the absence of aminopropanolphosphate, but addition of 1-amino-2-propanol to the medium can reverse the effect ?
-
 ?
6.3.1.10 additional information Halobacterium sp. NRC-1 inactivation of cobD, encoding threonine-phosphate decarboxylase, EC 4.1.1.81, prevents salvaging of Cbi, because AdoCby is not converted to AdoCbi-P in the absence of aminopropanolphosphate, but addition of 1-amino-2-propanol to the medium can reverse the effect ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.62 Cereibacter sphaeroides
-
-
-
3.5.1.90 Aeropyrum pernix
-
-
-
3.5.1.90 Cereibacter sphaeroides 2.4.1
-
-
-
3.5.1.90 Dehalococcoides mccartyi
-
-
-
3.5.1.90 Ferroplasma acidarmanus
-
-
-
3.5.1.90 Halalkalibacterium halodurans
-
-
-
3.5.1.90 Methanocaldococcus jannaschii
-
-
-
3.5.1.90 Methanosarcina mazei
-
-
-
3.5.1.90 Pyrococcus furiosus
-
-
-
3.5.1.90 Rhodospirillum rubrum
-
-
-
3.5.1.90 Streptomyces coelicolor
-
-
-
6.3.1.10 Cereibacter sphaeroides
-
-
-
6.3.1.10 Halobacterium sp.
-
-
-
6.3.1.10 Halobacterium sp. NRC-1
-
-
-
6.3.1.10 Methanosarcina mazei
-
-
-
6.3.1.10 Salmonella enterica
-
 serovar Typhimurium, strain JE8312
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.62 cell-free extracts are prepared Cereibacter sphaeroides

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.62 GTP + adenosylcobinamide phosphate
-
 Cereibacter sphaeroides diphosphate + adenosylcobinamide-GDP
-
 ?
3.5.1.90 adenosylcobinamide + H2O
-
 Pyrococcus furiosus adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
3.5.1.90 adenosylcobinamide + H2O
-
 Streptomyces coelicolor adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
3.5.1.90 adenosylcobinamide + H2O
-
 Rhodospirillum rubrum adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
3.5.1.90 adenosylcobinamide + H2O
-
 Methanocaldococcus jannaschii adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
3.5.1.90 adenosylcobinamide + H2O
-
 Methanosarcina mazei adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
3.5.1.90 adenosylcobinamide + H2O
-
 Halalkalibacterium halodurans adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
3.5.1.90 adenosylcobinamide + H2O
-
 Dehalococcoides mccartyi adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
3.5.1.90 adenosylcobinamide + H2O
-
 Aeropyrum pernix adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
3.5.1.90 adenosylcobinamide + H2O
-
 Ferroplasma acidarmanus adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
3.5.1.90 adenosylcobinamide + H2O
-
 Cereibacter sphaeroides 2.4.1 adenosylcobyric acid + (R)-1-aminopropan-2-ol
-
 ?
6.3.1.10 ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate
-
 Cereibacter sphaeroides ADP + phosphate + adenosylcobinamide phosphate
-
 ?
6.3.1.10 ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate
-
 Salmonella enterica ADP + phosphate + adenosylcobinamide phosphate
-
 ?
6.3.1.10 ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate
-
 Methanosarcina mazei ADP + phosphate + adenosylcobinamide phosphate
-
 ?
6.3.1.10 ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate
-
 Halobacterium sp. ADP + phosphate + adenosylcobinamide phosphate
-
 ?
6.3.1.10 ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate the enzyme is involved in the cobinamide salvaging pathways in bacteria and archaea, phylogenetic correlation, overview Cereibacter sphaeroides ADP + phosphate + adenosylcobinamide phosphate
-
 ?
6.3.1.10 ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate the enzyme is involved in the cobinamide salvaging pathways in bacteria and archaea, phylogenetic correlation, overview Halobacterium sp. ADP + phosphate + adenosylcobinamide phosphate
-
 ?
6.3.1.10 ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate the enzyme is involved in the the cobinamide salvaging pathways in bacteria and archaea, phylogenetic correlation, overview Methanosarcina mazei ADP + phosphate + adenosylcobinamide phosphate
-
 ?
6.3.1.10 ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate the enzyme is involved in the the cobinamide salvaging pathways in bacteria and archaea, Salmonella enterica serovar Typhimurium is unable to salvage cobinamide due to a lack of CbiZ, AdoCbi amidohydrolase, phylogenetic correlation, overview Salmonella enterica ADP + phosphate + adenosylcobinamide phosphate
-
 ?
6.3.1.10 ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate
-
 Halobacterium sp. NRC-1 ADP + phosphate + adenosylcobinamide phosphate
-
 ?
6.3.1.10 ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate the enzyme is involved in the cobinamide salvaging pathways in bacteria and archaea, phylogenetic correlation, overview Halobacterium sp. NRC-1 ADP + phosphate + adenosylcobinamide phosphate
-
 ?
6.3.1.10 additional information inactivation of cobD, encoding threonine-phosphate decarboxylase, EC 4.1.1.81, prevents salvaging of Cbi, because AdoCby is not converted to AdoCbi-P in the absence of aminopropanolphosphate, but addition of 1-amino-2-propanol to the medium can reverse the effect Cereibacter sphaeroides ?
-
 ?
6.3.1.10 additional information inactivation of cobD, encoding threonine-phosphate decarboxylase, EC 4.1.1.81, prevents salvaging of Cbi, because AdoCby is not converted to AdoCbi-P in the absence of aminopropanolphosphate, but addition of 1-amino-2-propanol to the medium can reverse the effect Methanosarcina mazei ?
-
 ?
6.3.1.10 additional information inactivation of cobD, encoding threonine-phosphate decarboxylase, EC 4.1.1.81, prevents salvaging of Cbi, because AdoCby is not converted to AdoCbi-P in the absence of aminopropanolphosphate, but addition of 1-amino-2-propanol to the medium can reverse the effect Halobacterium sp. ?
-
 ?
6.3.1.10 additional information inactivation of cobD, encoding threonine-phosphate decarboxylase, EC 4.1.1.81, prevents salvaging of Cbi, because AdoCby is not converted to AdoCbi-P in the absence of aminopropanolphosphate, but addition of 1-amino-2-propanol to the medium can reverse the effect Halobacterium sp. NRC-1 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.62 CobP bifunctional enzyme with kinase and guanylyltransferase activity Cereibacter sphaeroides
2.7.7.62 CobP/CobU
-
 Cereibacter sphaeroides
2.7.7.62 NTP:AdoCbi kinase, GTP:AdoCbi-P guanylyltransferase
-
 Cereibacter sphaeroides
3.5.1.90 AdoCbi amidohydrolase
-
 Pyrococcus furiosus
3.5.1.90 AdoCbi amidohydrolase
-
 Streptomyces coelicolor
3.5.1.90 AdoCbi amidohydrolase
-
 Rhodospirillum rubrum
3.5.1.90 AdoCbi amidohydrolase
-
 Methanocaldococcus jannaschii
3.5.1.90 AdoCbi amidohydrolase
-
 Methanosarcina mazei
3.5.1.90 AdoCbi amidohydrolase
-
 Halalkalibacterium halodurans
3.5.1.90 AdoCbi amidohydrolase
-
 Dehalococcoides mccartyi
3.5.1.90 AdoCbi amidohydrolase
-
 Aeropyrum pernix
3.5.1.90 AdoCbi amidohydrolase
-
 Ferroplasma acidarmanus
3.5.1.90 AdoCbi amidohydrolase
-
 Cereibacter sphaeroides 2.4.1
3.5.1.90 CbiZ
-
 Pyrococcus furiosus
3.5.1.90 CbiZ
-
 Streptomyces coelicolor
3.5.1.90 CbiZ
-
 Rhodospirillum rubrum
3.5.1.90 CbiZ
-
 Methanocaldococcus jannaschii
3.5.1.90 CbiZ
-
 Methanosarcina mazei
3.5.1.90 CbiZ
-
 Halalkalibacterium halodurans
3.5.1.90 CbiZ
-
 Dehalococcoides mccartyi
3.5.1.90 CbiZ
-
 Aeropyrum pernix
3.5.1.90 CbiZ
-
 Ferroplasma acidarmanus
3.5.1.90 CbiZ
-
 Cereibacter sphaeroides 2.4.1
3.5.1.90 corrinoid amidohydrolase
-
 Pyrococcus furiosus
3.5.1.90 corrinoid amidohydrolase
-
 Streptomyces coelicolor
3.5.1.90 corrinoid amidohydrolase
-
 Rhodospirillum rubrum
3.5.1.90 corrinoid amidohydrolase
-
 Methanocaldococcus jannaschii
3.5.1.90 corrinoid amidohydrolase
-
 Methanosarcina mazei
3.5.1.90 corrinoid amidohydrolase
-
 Halalkalibacterium halodurans
3.5.1.90 corrinoid amidohydrolase
-
 Dehalococcoides mccartyi
3.5.1.90 corrinoid amidohydrolase
-
 Aeropyrum pernix
3.5.1.90 corrinoid amidohydrolase
-
 Ferroplasma acidarmanus
3.5.1.90 corrinoid amidohydrolase
-
 Cereibacter sphaeroides 2.4.1
6.3.1.10 AdoCbi-P synthetase
-
 Cereibacter sphaeroides
6.3.1.10 AdoCbi-P synthetase
-
 Salmonella enterica
6.3.1.10 AdoCbi-P synthetase
-
 Methanosarcina mazei
6.3.1.10 AdoCbi-P synthetase
-
 Halobacterium sp.
6.3.1.10 CbiB
-
 Cereibacter sphaeroides
6.3.1.10 CbiB
-
 Salmonella enterica
6.3.1.10 CbiB
-
 Methanosarcina mazei
6.3.1.10 CbiB
-
 Halobacterium sp.
6.3.1.10 CbiB synthetase
-
 Cereibacter sphaeroides
6.3.1.10 CbiB synthetase
-
 Methanosarcina mazei
6.3.1.10 CbiB synthetase
-
 Halobacterium sp.

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.7.62 30
-
 activity assay Cereibacter sphaeroides
3.5.1.90 30
-
 activity assay Pyrococcus furiosus
3.5.1.90 30
-
 activity assay Streptomyces coelicolor
3.5.1.90 30
-
 activity assay Rhodospirillum rubrum
3.5.1.90 30
-
 activity assay Methanocaldococcus jannaschii
3.5.1.90 30
-
 activity assay Methanosarcina mazei
3.5.1.90 30
-
 activity assay Halalkalibacterium halodurans
3.5.1.90 30
-
 activity assay Dehalococcoides mccartyi
3.5.1.90 30
-
 activity assay Aeropyrum pernix
3.5.1.90 30
-
 activity assay Ferroplasma acidarmanus
3.5.1.90 30
-
 activity assay Cereibacter sphaeroides 2.4.1

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.62 8.5
-
 activity assay Cereibacter sphaeroides
3.5.1.90 7.5
-
 activity assay Pyrococcus furiosus
3.5.1.90 7.5
-
 activity assay Streptomyces coelicolor
3.5.1.90 7.5
-
 activity assay Rhodospirillum rubrum
3.5.1.90 7.5
-
 activity assay Methanocaldococcus jannaschii
3.5.1.90 7.5
-
 activity assay Methanosarcina mazei
3.5.1.90 7.5
-
 activity assay Halalkalibacterium halodurans
3.5.1.90 7.5
-
 activity assay Dehalococcoides mccartyi
3.5.1.90 7.5
-
 activity assay Aeropyrum pernix
3.5.1.90 7.5
-
 activity assay Ferroplasma acidarmanus
3.5.1.90 7.5
-
 activity assay Cereibacter sphaeroides 2.4.1

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.1.10 ATP
-
 Cereibacter sphaeroides
6.3.1.10 ATP
-
 Salmonella enterica
6.3.1.10 ATP
-
 Methanosarcina mazei
6.3.1.10 ATP
-
 Halobacterium sp.