Literature summary extracted from

Lindsay, M.E.; Gluenz, E.; Gull, K.; Englund, P.T.
A new function of Trypanosoma brucei mitochondrial topoisomerase II is to maintain kinetoplast DNA network topology (2008), Mol. Microbiol., 70, 1465-1476.

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
5.6.2.2	mitochondrion	-	Trypanosoma brucei	5739	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5.6.2.2	additional information	Trypanosoma brucei	mitochondrial topoisomerase II maintains kinetoplast DNA network topology by constantly remodeling the network during replication to maintain a proper minicircle density and network structure	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
5.6.2.2	Trypanosoma brucei	-	cell line 29-13	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5.6.2.2	additional information	mitochondrial topoisomerase II maintains kinetoplast DNA network topology by constantly remodeling the network during replication to maintain a proper minicircle density and network structure	Trypanosoma brucei	?	-	?
5.6.2.2	network of DNA rings + ATP + H2O	-	Trypanosoma brucei	monomer DNA circles + ADP + phosphate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
5.6.2.2	TOP2mt	-	Trypanosoma brucei
5.6.2.2	Topoisomerase II	-	Trypanosoma brucei

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
5.6.2.2	ATP	-	Trypanosoma brucei

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)