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Literature summary extracted from

  • Helling, S.; Vogt, S.; Rhiel, A.; Ramzan, R.; Wen, L.; Marcus, K.; Kadenbach, B.
    Phosphorylation and kinetics of mammalian cytochrome c oxidase (2008), Mol. Cell. Proteomics, 7, 1714-1724.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
7.1.1.9 medicine relationship between the allosteric ATP-inhibition and phosphorylation of CcO subunit I, which apparently occurs in living cells, but is lost under stress (e.g. hypoxic stress) Rattus norvegicus
7.1.1.9 medicine relationship between the allosteric ATP-inhibition and phosphorylation of CcO subunit I, which apparently occurs in living cells, but is lost under stress (e.g. hypoxic stress) Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.9 additional information incubation of the isolated enzyme with protein kinase A, cAMP, and ATP results in serine and threonine phosphorylation of CcO subunit I, which is correlated with sigmoidal inhibition kinetics in the presence of ATP Bos taurus
7.1.1.9 additional information rapid isolation of mitochondria from rat heart in the presence of various protein phosphatase inhibitors (in the presence of 25 mM NaF, 5 mM sodium vanadate, 10 nM okadaic acid, 2 mM EGTA, and 0.2% bovine serum albumin) results in CcO kinetics with allosteric ATP-inhibition and phosphorylation of subunit I at serine, threonine, and tyrosine Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.9 mitochondrion
-
 Rattus norvegicus 5739
-
7.1.1.9 mitochondrion
-
 Bos taurus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.9 Bos taurus
-
-
-
7.1.1.9 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
7.1.1.9 by gel filtration Rattus norvegicus
7.1.1.9 by gel filtration Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.9 heart
-
 Rattus norvegicus
-
7.1.1.9 heart
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.9 reduced cytochrome c + O2 + H+
-
 Rattus norvegicus oxidized cytochrome c + H2O
-
 ?
7.1.1.9 reduced cytochrome c + O2 + H+
-
 Bos taurus oxidized cytochrome c + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.9 CCO
-
 Rattus norvegicus
7.1.1.9 CCO
-
 Bos taurus
7.1.1.9 cytochrome c oxidase
-
 Rattus norvegicus
7.1.1.9 cytochrome c oxidase
-
 Bos taurus