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Literature summary extracted from

  • Alfa Cisse, M.; Louis, K.; Braun, U.; Mari, B.; Leitges, M.; Slack, B.E.; Fisher, A.; Auberger, P.; Checler, F.; Vincent, B.
    Isoform-specific contribution of protein kinase C to prion processing (2008), Mol. Cell. Neurosci., 39, 400-410.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.13 additional information the activation of PKCalpha isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1) Homo sapiens
2.7.11.13 additional information the activation of PKCdelta isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1) Homo sapiens
2.7.11.13 additional information the activation of PKCepsilon isoform leads to increased N1 secretion via the phosphorylation and activation of ADAM17, a process that likely accounts for M1/M3 muscarinic receptors-mediated control of N1 production (the cellular prion protein is physiologically cleaved in the middle of its 106-126 putative toxic core, at the 111/112 peptidyl bond, thus generating an amino-terminal fragment referred to as N1) Homo sapiens
2.7.11.13 phorbol-ester-12-13-dibutyrate
-
 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.13 expressed in HEK-293 cells and human-derived rhabdhomyosarcoma cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.13 GF109203X inhibits all PKC isozymes, except PKCmu Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.13 Homo sapiens P17252
-
-
2.7.11.13 Homo sapiens Q02156
-
-
2.7.11.13 Homo sapiens Q05513
-
-
2.7.11.13 Homo sapiens Q05655
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.13 ATP + ADAM17
-
 Homo sapiens ADP + phosphorylated ADAM17
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.13 PKCalpha isozyme Homo sapiens
2.7.11.13 PKCdelta isozyme Homo sapiens
2.7.11.13 PKCepsilon isozyme Homo sapiens
2.7.11.13 PKCzeta isozyme Homo sapiens