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Literature summary extracted from

  • Janovska, A.; Hatzinikolas, G.; Staikopoulos, V.; McInerney, J.; Mano, M.; Wittert, G.A.
    AMPK and ACC phosphorylation: effect of leptin, muscle fibre type and obesity (2008), Mol. Cell. Endocrinol., 284, 1-10.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.27 cAMP
-
 Rattus norvegicus
2.7.11.27 leptin stimulates fatty acid oxidation via the phosphorylation of AMPK and acetyl-CoA carboxylase, the stimulation by leptin is muscle fibre type-dependent and fails in diet-induced obesity Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.27 ATP + [acetyl-CoA carboxylase] Rattus norvegicus
-
 ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
2.7.11.27 additional information Rattus norvegicus leptin stimulates fatty acid oxidation via the phosphorylation of AMP-activated protein kinase and acetyl-CoA carboxylase. Obesity is associated with resistance to the effects of leptin, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.27 Rattus norvegicus
-
 lean and obese Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.27 skeletal muscle stimulation of AMPKalpha by leptin differs in tissue of lean and obese rats, overview Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.27 ATP + [acetyl-CoA carboxylase]
-
 Rattus norvegicus ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
2.7.11.27 additional information leptin stimulates fatty acid oxidation via the phosphorylation of AMP-activated protein kinase and acetyl-CoA carboxylase. Obesity is associated with resistance to the effects of leptin, overview Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.27 AMPK
-
 Rattus norvegicus
2.7.11.27 AMPKalpha
-
 Rattus norvegicus
2.7.11.27 cAMP-activated protein kinase
-
 Rattus norvegicus