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Literature summary extracted from

  • Petersen, R.K.; Madsen, L.; Pedersen, L.M.; Hallenborg, P.; Hagland, H.; Viste, K.; Doskeland, S.O.; Kristiansen, K.
    Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes (2008), Mol. Cell. Biol., 28, 3804-3816.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 8-p-chloro-phenylthio-cAMP 0.1 mM activates Mus musculus
2.7.11.11 forskolin 0.05 mM activates Mus musculus
2.7.11.11 IBMX 0.5 mM activates Mus musculus
2.7.11.11 additional information not activated by 8-(4-chlorophenylthio)-2'-O-methyl-cAMP Mus musculus
2.7.11.11 N6-benzoyl-cAMP 0.1 mM activates Mus musculus
2.7.11.11 N6-Monobutyryl-cAMP 0.1 mM activates Mus musculus

Application

EC Number Application Comment Organism
2.7.11.11 medicine cAMP-dependent protein kinase acts synergistically with exchange protein directly activated by cAMP to promote adipogenesis Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.11 H-89
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 3T3-L1 cell
-
 Mus musculus
-
2.7.11.11 adipocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + cAMP-responsive element-binding protein
-
 Mus musculus ADP + phosphorylated cAMP-responsive element-binding protein
-
 ?
2.7.11.11 ATP + Kemptide
-
 Mus musculus ADP + Kemptide phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 PKA
-
 Mus musculus
2.7.11.11 protein kinase A
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Mus musculus
2.7.11.11 cAMP dependent Mus musculus