Literature summary extracted from
Li, D.; Urs, A.N.; Allegood, J.; Leon, A.; Merrill, A.H.; Sewer, M.B.
Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17 (2007), Mol. Cell. Biol., 27, 6669-6685.
Activating Compound
EC Number |
Activating Compound |
Comment |
Organism |
Structure |
---|
2.7.1.107 |
cAMP |
stimulates nuclear diacylglycerol kinase catalytic activity |
Homo sapiens |
|
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
2.7.1.107 |
additional information |
silencing of diacylglycerol kinase theta by siRNA expression inhibits cAMP-dependent CYP17 transcription. LXXLL motifs in diacylglycerol kinase theta mediate a direct interaction of steroidogenic factor 1 with the kinase and may facilitate binding of phosphatidic acid to the receptor |
Homo sapiens |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
2.7.1.107 |
Homo sapiens |
- |
- |
- |
Source Tissue
EC Number |
Source Tissue |
Comment |
Organism |
Textmining |
---|
2.7.1.107 |
NCI-H295R cell |
activation of the adrenocorticotropin/cAMP signal transduction cascade rapidly increases nuclear diacylglycerol kinase activity and phosphatidic acid production. LXXLL motifs in diacylglycerol kinase theta mediate a direct interaction of nuclear receptor steroidogenic factor 1 with the kinase and may facilitate binding of phosphatidic acid to the receptor |
Homo sapiens |
- |
Subunits
EC Number |
Subunits |
Comment |
Organism |
---|
2.7.1.107 |
More |
nuclear receptor steroidogenic factor 1 binds to diacylglycerol kinase zeta and diacylglycerol kinase theta in vitro and in vivo |
Homo sapiens |