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Literature summary extracted from

  • Li, D.; Urs, A.N.; Allegood, J.; Leon, A.; Merrill, A.H.; Sewer, M.B.
    Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17 (2007), Mol. Cell. Biol., 27, 6669-6685.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.107 cAMP stimulates nuclear diacylglycerol kinase catalytic activity Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.107 additional information silencing of diacylglycerol kinase theta by siRNA expression inhibits cAMP-dependent CYP17 transcription. LXXLL motifs in diacylglycerol kinase theta mediate a direct interaction of steroidogenic factor 1 with the kinase and may facilitate binding of phosphatidic acid to the receptor Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.107 Homo sapiens
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.107 NCI-H295R cell activation of the adrenocorticotropin/cAMP signal transduction cascade rapidly increases nuclear diacylglycerol kinase activity and phosphatidic acid production. LXXLL motifs in diacylglycerol kinase theta mediate a direct interaction of nuclear receptor steroidogenic factor 1 with the kinase and may facilitate binding of phosphatidic acid to the receptor Homo sapiens
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Subunits

EC Number Subunits Comment Organism
2.7.1.107 More nuclear receptor steroidogenic factor 1 binds to diacylglycerol kinase zeta and diacylglycerol kinase theta in vitro and in vivo Homo sapiens