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Literature summary extracted from

  • Meza-Avina, M.E.; Wei, L.; Buhendwa, M.G.; Poduch, E.; Bello, A.M.; Pai, E.F.; Kotra, L.P.
    Inhibition of orotidine 5-monophosphate decarboxylase and its therapeutic potential (2008), Mini Rev. Med. Chem., 8, 239-247.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.23 6-aminouridine 5'-monophosphate
-
 Bacillus subtilis
4.1.1.23 6-aminouridine 5'-monophosphate
-
 Escherichia coli
4.1.1.23 6-aminouridine 5'-monophosphate
-
 Homo sapiens
4.1.1.23 6-aminouridine 5'-monophosphate
-
 Methanococcus thermoautotrophicum
4.1.1.23 6-aminouridine 5'-monophosphate
-
 Plasmodium falciparum
4.1.1.23 6-aminouridine 5'-monophosphate
-
 Plasmodium vivax
4.1.1.23 6-aminouridine 5'-monophosphate
-
 Saccharomyces cerevisiae
4.1.1.23 6-azauridine 5'-monophosphate
-
 Bacillus subtilis
4.1.1.23 6-azauridine 5'-monophosphate
-
 Escherichia coli
4.1.1.23 6-azauridine 5'-monophosphate
-
 Homo sapiens
4.1.1.23 6-azauridine 5'-monophosphate
-
 Methanococcus thermoautotrophicum
4.1.1.23 6-azauridine 5'-monophosphate
-
 Plasmodium falciparum
4.1.1.23 6-azauridine 5'-monophosphate
-
 Plasmodium vivax
4.1.1.23 6-azauridine 5'-monophosphate
-
 Saccharomyces cerevisiae
4.1.1.23 6-cyanouridine 5'-monophosphate
-
 Bacillus subtilis
4.1.1.23 6-cyanouridine 5'-monophosphate
-
 Escherichia coli
4.1.1.23 6-cyanouridine 5'-monophosphate
-
 Homo sapiens
4.1.1.23 6-cyanouridine 5'-monophosphate
-
 Methanococcus thermoautotrophicum
4.1.1.23 6-cyanouridine 5'-monophosphate
-
 Plasmodium falciparum
4.1.1.23 6-cyanouridine 5'-monophosphate
-
 Plasmodium vivax
4.1.1.23 6-cyanouridine 5'-monophosphate
-
 Saccharomyces cerevisiae
4.1.1.23 6-iodouridine 5'-monophosphate
-
 Bacillus subtilis
4.1.1.23 6-iodouridine 5'-monophosphate
-
 Escherichia coli
4.1.1.23 6-iodouridine 5'-monophosphate
-
 Homo sapiens
4.1.1.23 6-iodouridine 5'-monophosphate
-
 Methanococcus thermoautotrophicum
4.1.1.23 6-iodouridine 5'-monophosphate
-
 Plasmodium falciparum
4.1.1.23 6-iodouridine 5'-monophosphate
-
 Plasmodium vivax
4.1.1.23 6-iodouridine 5'-monophosphate
-
 Saccharomyces cerevisiae
4.1.1.23 6-thiocarboxamidouridine 5'-monophosphate
-
 Bacillus subtilis
4.1.1.23 6-thiocarboxamidouridine 5'-monophosphate
-
 Escherichia coli
4.1.1.23 6-thiocarboxamidouridine 5'-monophosphate
-
 Homo sapiens
4.1.1.23 6-thiocarboxamidouridine 5'-monophosphate
-
 Methanococcus thermoautotrophicum
4.1.1.23 6-thiocarboxamidouridine 5'-monophosphate
-
 Plasmodium falciparum
4.1.1.23 6-thiocarboxamidouridine 5'-monophosphate
-
 Plasmodium vivax
4.1.1.23 6-thiocarboxamidouridine 5'-monophosphate
-
 Saccharomyces cerevisiae
4.1.1.23 barbituric acid ribonucleoside 5'-monophosphate
-
 Bacillus subtilis
4.1.1.23 barbituric acid ribonucleoside 5'-monophosphate
-
 Escherichia coli
4.1.1.23 barbituric acid ribonucleoside 5'-monophosphate
-
 Homo sapiens
4.1.1.23 barbituric acid ribonucleoside 5'-monophosphate
-
 Methanococcus thermoautotrophicum
4.1.1.23 barbituric acid ribonucleoside 5'-monophosphate
-
 Plasmodium falciparum
4.1.1.23 barbituric acid ribonucleoside 5'-monophosphate
-
 Plasmodium vivax
4.1.1.23 barbituric acid ribonucleoside 5'-monophosphate
-
 Saccharomyces cerevisiae
4.1.1.23 pyrazofurin 5'-monophosphate
-
 Bacillus subtilis
4.1.1.23 pyrazofurin 5'-monophosphate
-
 Escherichia coli
4.1.1.23 pyrazofurin 5'-monophosphate
-
 Homo sapiens
4.1.1.23 pyrazofurin 5'-monophosphate
-
 Methanococcus thermoautotrophicum
4.1.1.23 pyrazofurin 5'-monophosphate
-
 Plasmodium falciparum
4.1.1.23 pyrazofurin 5'-monophosphate
-
 Plasmodium vivax
4.1.1.23 pyrazofurin 5'-monophosphate
-
 Saccharomyces cerevisiae
4.1.1.23 xanthosine 5'-monophosphate
-
 Bacillus subtilis
4.1.1.23 xanthosine 5'-monophosphate
-
 Escherichia coli
4.1.1.23 xanthosine 5'-monophosphate
-
 Homo sapiens
4.1.1.23 xanthosine 5'-monophosphate
-
 Methanococcus thermoautotrophicum
4.1.1.23 xanthosine 5'-monophosphate
-
 Plasmodium falciparum
4.1.1.23 xanthosine 5'-monophosphate
-
 Plasmodium vivax
4.1.1.23 xanthosine 5'-monophosphate
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.23 Orotidine 5'-phosphate Bacillus subtilis
-
 UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate Escherichia coli
-
 UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate Homo sapiens
-
 UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate Saccharomyces cerevisiae
-
 UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate Plasmodium falciparum
-
 UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate Plasmodium vivax
-
 UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate Methanococcus thermoautotrophicum
-
 UMP + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.23 Bacillus subtilis
-
-
-
4.1.1.23 Escherichia coli
-
-
-
4.1.1.23 Homo sapiens
-
-
-
4.1.1.23 Methanococcus thermoautotrophicum
-
-
-
4.1.1.23 Plasmodium falciparum
-
-
-
4.1.1.23 Plasmodium vivax
-
-
-
4.1.1.23 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.23 Orotidine 5'-phosphate
-
 Bacillus subtilis UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate
-
 Escherichia coli UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate
-
 Homo sapiens UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate
-
 Saccharomyces cerevisiae UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate
-
 Plasmodium falciparum UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate
-
 Plasmodium vivax UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate
-
 Methanococcus thermoautotrophicum UMP + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.23 dimer
-
 Bacillus subtilis
4.1.1.23 dimer
-
 Escherichia coli
4.1.1.23 dimer
-
 Homo sapiens
4.1.1.23 dimer
-
 Saccharomyces cerevisiae
4.1.1.23 dimer
-
 Plasmodium falciparum
4.1.1.23 dimer
-
 Plasmodium vivax
4.1.1.23 dimer
-
 Methanococcus thermoautotrophicum

Synonyms

EC Number Synonyms Comment Organism
4.1.1.23 ODCase
-
 Bacillus subtilis
4.1.1.23 ODCase
-
 Escherichia coli
4.1.1.23 ODCase
-
 Homo sapiens
4.1.1.23 ODCase
-
 Saccharomyces cerevisiae
4.1.1.23 ODCase
-
 Plasmodium falciparum
4.1.1.23 ODCase
-
 Plasmodium vivax
4.1.1.23 ODCase
-
 Methanococcus thermoautotrophicum
4.1.1.23 Orotidine 5'-monophosphate decarboxylase
-
 Bacillus subtilis
4.1.1.23 Orotidine 5'-monophosphate decarboxylase
-
 Escherichia coli
4.1.1.23 Orotidine 5'-monophosphate decarboxylase
-
 Homo sapiens
4.1.1.23 Orotidine 5'-monophosphate decarboxylase
-
 Saccharomyces cerevisiae
4.1.1.23 Orotidine 5'-monophosphate decarboxylase
-
 Plasmodium falciparum
4.1.1.23 Orotidine 5'-monophosphate decarboxylase
-
 Plasmodium vivax
4.1.1.23 Orotidine 5'-monophosphate decarboxylase
-
 Methanococcus thermoautotrophicum