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Literature summary extracted from

  • Paeshuyse, J.; Chezal, J.M.; Froeyen, M.; Leyssen, P.; Dutartre, H.; Vrancken, R.; Canard, B.; Letellier, C.; Li, T.; Mittendorfer, H.; Koenen, F.; Kerkhofs, P.; De Clercq, E.; Herdewijn, P.; Puerstinger, G.; Gueiffier, A.; Chavignon, O.; Teulade, J.C.; Neyts, J.
    The imidazopyrrolopyridine analogue AG110 is a novel, highly selective inhibitor of pestiviruses that targets the viral RNA-dependent RNA polymerase at a hot spot for inhibition of viral replication (2007), J. Virol., 81, 11046-11053.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.48 expressed in Escherichia coli Bovine viral diarrhea virus 1

Protein Variants

EC Number Protein Variants Comment Organism
2.7.7.48 E291G mutant is insensitive against inhibitor ethyl 2-methylimidazo[1,2-a]pyrrolo[2,3-c]pyridin-8-carboxylate Bovine viral diarrhea virus 1
2.7.7.48 F224S mutant is insensitive against inhibitors ethyl 2-methylimidazo[1,2-a]pyrrolo[2,3-c]pyridin-8-carboxylate, 5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine, and VP32947 Bovine viral diarrhea virus 1

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.48 1-[2-(diethylamino)ethyl]-6-(1H-imidazol-1-yl)-1,3-dihydro-2H-benzimidazol-2-one
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Bovine viral diarrhea virus 1
2.7.7.48 5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine
-
Bovine viral diarrhea virus 1
2.7.7.48 ethyl 2-methylimidazo[1,2-a]pyrrolo[2,3-c]pyridin-8-carboxylate AG110, potent inhibitor of pestivirus replication, does not inhibit the in vitro activity of recombinant bovine viral diarrhea virus RdRp but inhibits the activity of bovine viral diarrhea virus replication complexes Bovine viral diarrhea virus 1
2.7.7.48 N-propyl-N-[2-(2H-1,2,4-triazino[5,6-b]indol-3-ylthio)ethyl]-1-propanamine VP32947 Bovine viral diarrhea virus 1

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 Bovine viral diarrhea virus 1 P19711 strains Marloie, NADL, and 3435
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.48
-
Bovine viral diarrhea virus 1

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn
-
Bovine viral diarrhea virus 1 diphosphate + RNAn+1
-
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Synonyms

EC Number Synonyms Comment Organism
2.7.7.48 RDRP
-
Bovine viral diarrhea virus 1
2.7.7.48 RNA-dependent RNA polymerase
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Bovine viral diarrhea virus 1