EC Number | Cloned (Comment) | Organism |
---|---|---|
3.1.1.23 | expressed in Escherichia coli BL21 (DE3) cells | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.1.23 | 0.0088 | - |
arachidonoyl-7-hydroxy-6-methoxy-4-methylcoumarin ester | recombinant enzyme, in TME buffer, at 37°C | Homo sapiens | |
3.1.1.23 | 0.0197 | - |
2-arachidonoylglycerol | recombinant enzyme, in TME buffer, at 37°C | Homo sapiens | |
3.1.1.23 | 0.0336 | - |
2-arachidonoylglycerol | native enzyme, in TME buffer, at 37°C | Rattus norvegicus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.1.1.23 | 35000 | - |
SDS-PAGE | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.23 | 2-arachidonoylglycerol + H2O | Rattus norvegicus | - |
arachidonic acid + glycerol | - |
? | |
3.1.1.23 | 2-arachidonoylglycerol + H2O | Homo sapiens | MGL modulates endocannabinoid signaling in vivo by inactivating 2-arachidonoylglycerol (2-AG), the main endogenous agonist for central CB1 and peripheral CB2 cannabinoid receptors | arachidonic acid + glycerol | - |
? | |
3.1.1.23 | arachidonoyl-7-hydroxy-6-methoxy-4-methylcoumarin ester + H2O | Homo sapiens | - |
arachidonic acid + 7-hydroxy-6-methoxy-4-methylcoumarin | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.23 | Homo sapiens | Q99685 | - |
- |
3.1.1.23 | Rattus norvegicus | Q8R431 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.1.1.23 | immobilized metal affinity chromatography | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.1.23 | brain | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.23 | 2-arachidonoylglycerol + H2O | - |
Rattus norvegicus | arachidonic acid + glycerol | - |
? | |
3.1.1.23 | 2-arachidonoylglycerol + H2O | MGL modulates endocannabinoid signaling in vivo by inactivating 2-arachidonoylglycerol (2-AG), the main endogenous agonist for central CB1 and peripheral CB2 cannabinoid receptors | Homo sapiens | arachidonic acid + glycerol | - |
? | |
3.1.1.23 | arachidonoyl-7-hydroxy-6-methoxy-4-methylcoumarin ester + H2O | - |
Homo sapiens | arachidonic acid + 7-hydroxy-6-methoxy-4-methylcoumarin | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.1.23 | MGL | - |
Rattus norvegicus |
3.1.1.23 | MGL | - |
Homo sapiens |
3.1.1.23 | monoacylglycerol lipase | - |
Rattus norvegicus |
3.1.1.23 | monoacylglycerol lipase | - |
Homo sapiens |