Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Dev, S.; Mizuguchi, H.; Das, A.K.; Matsushita, C.; Maeyama, K.; Umehara, H.; Ohtoshi, T.; Kojima, J.; Nishida, K.; Takahashi, K.; Fukui, H.
    Suppression of histamine signaling by probiotic Lac-B: a possible mechanism of its anti-allergic effect (2008), J. Pharmacol. Sci., 107, 159-166.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.22 toluene 2,4-diisocyanate toluene 2,4-diisocyanate provocation causes acute allergy-like behaviors along with significant up-regulation of HDC mRNA expression and increased HDC activity Rattus norvegicus

Application

EC Number Application Comment Organism
4.1.1.22 medicine suppression of histamine signaling by inhibition of HDC may be a novel target of probiotics in preventing allergic diseases Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.22 additional information Lac-B (a mixture of freeze-dried Bifidobacterium infantis and Bifidobacterium longum) shows significant anti-allergic effect through suppression of both H1R and HDC gene expression followed by decrease in H1R, HDC protein level, and histamine content, oral administration of the Lac-B suspension significantly suppresses the toluene 2,4-diisocyanate-induced HDC mRNA up-regulation Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.22 nasal mucosa
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 L-histidine
-
 Rattus norvegicus histamine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.22 HDC
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.22 pyridoxal 5'-phosphate
-
 Rattus norvegicus