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Literature summary extracted from

  • Threlfell, S.; Sammut, S.; Menniti, F.S.; Schmidt, C.J.; West, A.R.
    Inhibition of phosphodiesterase 10A increases the responsiveness of striatal projection neurons to cortical stimulation (2009), J. Pharmacol. Exp. Ther., 328, 785-795.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.4.17 medicine genetic disruption or pharmacological inhibition of PDE10A reverses behavioral abnormalities associated with subcortical hyperdopaminergia Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.17 2-[[4-[4-pyridin-4-yl-1-(2,2, 2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline succinic acid selective PDE10A inhibitor, inhibition of striatal PDE10A activity increases the responsiveness of medium-sized spiny projection neurons to depolarising stimuli Rattus norvegicus
3.1.4.17 papaverine selective PDE10A inhibitor Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.17 corpus striatum dorsal striatum Rattus norvegicus
-
3.1.4.17 neuron PDE10A is highly expressed in striatal medium-sized spiny projection neurons Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.17 3',5'-cAMP + H2O
-
 Rattus norvegicus 5'-AMP
-
 ?
3.1.4.17 3',5'-cGMP + H2O
-
 Rattus norvegicus 5'-GMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.17 cyclic nucleotide phosphodiesterase 10A
-
 Rattus norvegicus
3.1.4.17 PDE10A
-
 Rattus norvegicus