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Literature summary extracted from

  • Webb, G.D.; Lim, L.H.; Oh, V.M.; Yeo, S.B.; Cheong, Y.P.; Ali, M.Y.; El Oakley, R.; Lee, C.N.; Wong, P.S.; Caleb, M.G.; Salto-Tellez, M.; Bhatia, M.; Chan, E.S.; Taylor, E.A.; Moore, P.K.
    Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery (2008), J. Pharmacol. Exp. Ther., 324, 876-882.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.4.1.1 expressed in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.1 DL-propargylglycine
-
 Homo sapiens
4.4.1.1 DL-propargylglycine
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.4.1.1 39700
-
 the 44.5 kDa bands for variant 1 of CSE are detected in all arteries tested with Western blotting. CSE variant 2 is also detected at 39.7 kDa in a few arteries, but the band is not as intense and is not detected in most arteries Homo sapiens
4.4.1.1 44500
-
 the 44.5 kDa bands for variant 1 of CSE are detected in all arteries tested with Western blotting. CSE variant 2 is also detected at 39.7 kDa in a few arteries, but the band is not as intense and is not detected in most arteries Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.1 Homo sapiens P32929
-
-
4.4.1.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.1 artery
-
 Rattus norvegicus
-
4.4.1.1 artery
-
 Homo sapiens
-
4.4.1.1 liver
-
 Rattus norvegicus
-
4.4.1.1 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.1 L-cysteine + H2O
-
 Rattus norvegicus sulfide + NH3 + pyruvate
-
 ?
4.4.1.1 L-cysteine + H2O
-
 Homo sapiens sulfide + NH3 + pyruvate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.1 CSE
-
 Rattus norvegicus
4.4.1.1 CSE
-
 Homo sapiens
4.4.1.1 cystathionine gamma-lyase
-
 Rattus norvegicus
4.4.1.1 cystathionine gamma-lyase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.1 pyridoxal 5'-phosphate
-
 Rattus norvegicus
4.4.1.1 pyridoxal 5'-phosphate
-
 Homo sapiens