Literature summary extracted from

Walker, J.R.; Rothman, S.C.; Poulter, C.D.
Synthesis and evaluation of substrate analogues as mechanism-based inhibitors of type II isopentenyl diphosphate isomerase (2008), J. Org. Chem., 73, 726-729.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
5.3.3.2	(E/Z)-3-cyclopropyl-2-buten-1-yl diphosphate	-	Thermus thermophilus
5.3.3.2	3-cyclopropyl-3-buten-1-yl diphosphate	-	Thermus thermophilus
5.3.3.2	3-oxiranyl-3-buten-1-yl diphosphate	irreversible	Thermus thermophilus

Organism

EC Number	Organism	UniProt	Comment	Textmining
5.3.3.2	Thermus thermophilus	-	-	-

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
5.3.3.2	0.0014	-	3-oxiranyl-3-buten-1-yl diphosphate	pH 7.0, 37°C	Thermus thermophilus

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
5.3.3.2	0.00114	-	pH 7.0, 37°C	Thermus thermophilus	3-oxiranyl-3-buten-1-yl diphosphate
5.3.3.2	0.1	-	25°C, pH 8.6	Thermus thermophilus	3-cyclopropyl-3-buten-1-yl diphosphate
5.3.3.2	0.278	-	25°C, pH 8.6	Thermus thermophilus	(E/Z)-3-cyclopropyl-2-buten-1-yl diphosphate

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Release 2023.1 (January 2023)