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Literature summary extracted from

  • Hsiao, Y.H.; Chen, P.S.; Yeh, S.H.; Lin, C.H.; Gean, P.W.
    N-acetylcysteine prevents beta-amyloid toxicity by a stimulatory effect on p35/cyclin-dependent kinase 5 activity in cultured cortical neurons (2008), J. Neurosci. Res., 86, 2685-2695.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.22 N-acetylcysteine 10 mM, increases cyclin-dependent kinase 5 phosphorylation, phosphorylation of Cdk5 on tyrosine 15 by c-Abl increases kinase activity of the p35/Cdk5 complex Rattus norvegicus
2.7.11.22 p35 monomeric Cdk5 has no enzymatic activity and requires association with a regulatory binding partner p35 for its activation Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.22 Butyrolactone 0.01 mM Rattus norvegicus
2.7.11.22 roscovitine 0.015 mM Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.22 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.22 cerebral cortical neuron
-
 Rattus norvegicus
-
2.7.11.22 primary culture
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.22 ATP + histone H1
-
 Rattus norvegicus ADP + phosphorylated histone H1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.22 Cdk5
-
 Rattus norvegicus
2.7.11.22 cyclin-dependent kinase 5
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.22 cyclin dependent on Rattus norvegicus