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Literature summary extracted from

  • Houston, C.M.; Hosie, A.M.; Smart, T.G.
    Distinct regulation of beta2 and beta3 subunit-containing cerebellar synaptic GABAA receptors by calcium/calmodulin-dependent protein kinase II (2008), J. Neurosci., 28, 7574-7584.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.17 A302R mutation impairs Ca2+/calmodulin-binding Rattus norvegicus
2.7.11.17 K42R mutation without enzymatic activity Rattus norvegicus
2.7.11.17 T286A the mutant is constitutively active and capable of only transient Ca2+-dependent activation Rattus norvegicus
2.7.11.17 T286D the mutant is constitutively active and Ca2+-independent Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 CaMK-II-Ntide specific CaMK-II inhibitory peptide Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ substrate activation, but not autophosphorylation dependent on Ca2+ Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 additional information Rattus norvegicus autophosphorylation is not dependent on calmodulin and Ca2+ ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.17
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 cerebellar granule cell
-
 Rattus norvegicus
-
2.7.11.17 cerebellum
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + GABA A receptor
-
 Rattus norvegicus ADP + phosphorylated GABA A receptor
-
 ?
2.7.11.17 additional information autophosphorylation is not dependent on calmodulin and Ca2+ Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 alpha-calcium/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
2.7.11.17 alpha-CaMK-II
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Rattus norvegicus
2.7.11.17 Calmodulin substrate activation, but not autophosphorylation is dependent on calmodulin Rattus norvegicus