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Literature summary extracted from
- Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors (2008), J. Neurosci., 28, 4385-4397.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.1 | Calmodulin | activates isozyme AC1 | Mus musculus |  |
| 4.6.1.1 | Calmodulin | activates isozyme AC8 | Mus musculus | |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 4.6.1.1 | additional information | increase of Fmr1 mRNA is attenuated in ACC slices from AC1 KO mice compared to wild-type mice, and induced phosphorylation of CREB is significantly attenuated in ACC slices from AC1 KO mice compared with WT mice | Mus musculus |
| 4.6.1.1 | additional information | the basal phosphorylation levels of CREB are not changed in ACC slices from AC8 KO mice | Mus musculus |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.11.17 | Ca2+ | dependent on | Mus musculus | |
| 4.6.1.1 | Ca2+ | activates isozyme AC1 | Mus musculus | |
| 4.6.1.1 | Ca2+ | activates isozyme AC8 | Mus musculus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.6.1.1 | ATP | Mus musculus | roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the upregulation of fragile X mental retardation protein, FMRP, by group I metabotropic glutamate receptors, mGluRs, in anterior cingulate cortex neurons probably through cAMP response element-binding protein activation, calcium is critical for the regulation of FMRP by group I mGluRs, overview. Isozyme AC1 may contribute to the activation of CREB caused by stimulating group I mGluRs, overview | 3',5'-cyclic-AMP + diphosphate | - |
? | |
| 4.6.1.1 | ATP | Mus musculus | roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the upregulation of fragile X mental retardation protein, FMRP, by group I metabotropic glutamate receptors, mGluRs, in anterior cingulate cortex neurons probably through cAMP response element-binding protein activation, calcium is critical for the regulation of FMRP by group I mGluRs, overview. Isozyme AC8 may contribute to the activation of CREB caused by stimulating group I mGluRs, overview | 3',5'-cyclic-AMP + diphosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.7.11.17 | Mus musculus | - |
- |
- |
| 4.6.1.1 | Mus musculus | O88444 | adult male C57BL/6 mice, isozyme AC1 | - |
| 4.6.1.1 | Mus musculus | P97490 | adult male C57BL/6 mice, isozyme AC8 | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 2.7.11.17 | anterior cingulate cortex | - |
Mus musculus | - |
| 2.7.11.17 | neuron | - |
Mus musculus | - |
| 4.6.1.1 | brain | - |
Mus musculus | - |
| 4.6.1.1 | neuron | anterior cingulate cortex, ACC, neurons from a key region involved in high brain cognitive and executive functions | Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.11.17 | ATP + cAMP response element-binding protein | - |
Mus musculus | ADP + phosphorylated cAMP response element-binding protein | - |
? | |
| 2.7.11.17 | ATP + group I metabotropic glutamate receptor | CaMKIV contributes to the upregulation of fragile X mental retardation protein induced by stimulating group I metabotropic glutamate receptors | Mus musculus | ADP + phosphorylated group I metabotropic glutamate receptor | - |
? | |
| 4.6.1.1 | ATP | - |
Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
| 4.6.1.1 | ATP | roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the upregulation of fragile X mental retardation protein, FMRP, by group I metabotropic glutamate receptors, mGluRs, in anterior cingulate cortex neurons probably through cAMP response element-binding protein activation, calcium is critical for the regulation of FMRP by group I mGluRs, overview. Isozyme AC1 may contribute to the activation of CREB caused by stimulating group I mGluRs, overview | Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
| 4.6.1.1 | ATP | roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the upregulation of fragile X mental retardation protein, FMRP, by group I metabotropic glutamate receptors, mGluRs, in anterior cingulate cortex neurons probably through cAMP response element-binding protein activation, calcium is critical for the regulation of FMRP by group I mGluRs, overview. Isozyme AC8 may contribute to the activation of CREB caused by stimulating group I mGluRs, overview | Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.7.11.17 | calcium/calmodulin-dependent protein kinase IV | - |
Mus musculus |
| 2.7.11.17 | CaMK | - |
Mus musculus |
| 4.6.1.1 | AC1 | - |
Mus musculus |
| 4.6.1.1 | AC8 | - |
Mus musculus |
| 4.6.1.1 | Ca2+/calmodulin-stimulated adenylyl cyclase 1 | - |
Mus musculus |
| 4.6.1.1 | calcium-stimulated adenylyl cyclase | - |
Mus musculus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.11.17 | ATP | - |
Mus musculus | |
| 2.7.11.17 | Calmodulin | dependent on | Mus musculus | |
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