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Literature summary extracted from

  • Xia, H.; Lazartigues, E.
    Angiotensin-converting enzyme 2 in the brain: properties and future directions (2008), J. Neurochem., 107, 1482-1494.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.17.23 development of a transgenic mouse model (syn-hACE2) where the full open reading frame of the human ACE2 gene is under the control of a synapsin promoter, allowing the hACE2 protein to be expressed specifically in neurons Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.17.23 Zn2+ metallopeptidase Homo sapiens
3.4.17.23 Zn2+ metallopeptidase Mus musculus
3.4.17.23 Zn2+ metallopeptidase Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.23 angiotensin II + H2O Homo sapiens the major role of ACE2 in Ang peptides metabolism is the production of Ang-(1-7). ACE2 also participates in the metabolism of other peptides non related to the renin-angiotensin system: apelin-13, neurotensin, kinetensin, dynorphin, [des-Arg9]-bradykinin, and [Lys-des-Arg9]-bradykinin angiotensin-(1-7) + Phe
-
?
3.4.17.23 additional information Homo sapiens the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Homo sapiens Q9BYF1
-
-
3.4.17.23 Mus musculus Q8R0I0
-
-
3.4.17.23 Rattus norvegicus Q5EGZ1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.23 brain
-
Rattus norvegicus
-
3.4.17.23 brain ACE2 is widespread throughout the brain, present in nuclei involved in the central regulation of cardiovascular function like the cardio-respiratory neurons of the brainstem, as well as in non-cardiovascular areas such as the motor cortex and raphe Homo sapiens
-
3.4.17.23 brain predominantly in neurons Mus musculus
-
3.4.17.23 kidney in salt-sensitive Sabra hypertensive (SBH/y) rats, ACE2 mRNA and protein expression are lower than that in salt-resistant Sabra normotensive (SBN/y) rats Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 angiotensin I + H2O the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited Homo sapiens angiotensin-(1-9) + Leu
-
?
3.4.17.23 angiotensin II + H2O
-
Mus musculus angiotensin-(1-7) + Phe
-
?
3.4.17.23 angiotensin II + H2O
-
Rattus norvegicus angiotensin-(1-7) + Phe
-
?
3.4.17.23 angiotensin II + H2O the major role of ACE2 in Ang peptides metabolism is the production of Ang-(1-7). ACE2 also participates in the metabolism of other peptides non related to the renin-angiotensin system: apelin-13, neurotensin, kinetensin, dynorphin, [des-Arg9]-bradykinin, and [Lys-des-Arg9]-bradykinin Homo sapiens angiotensin-(1-7) + Phe
-
?
3.4.17.23 angiotensin II + H2O ACE2 has approximately a 400fold greater affinity for Ang-II than Ang-I Homo sapiens angiotensin-(1-7) + Phe
-
?
3.4.17.23 additional information the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited Homo sapiens ?
-
?
3.4.17.23 additional information hydrolyses its substrates by removing a single amino acid from their respective C-terminal Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE 2
-
Homo sapiens
3.4.17.23 ACE 2
-
Mus musculus
3.4.17.23 ACE 2
-
Rattus norvegicus
3.4.17.23 Ang converting enzyme 2
-
Homo sapiens
3.4.17.23 Ang converting enzyme 2
-
Mus musculus
3.4.17.23 Ang converting enzyme 2
-
Rattus norvegicus
3.4.17.23 angiotensin converting enzyme 2
-
Homo sapiens
3.4.17.23 angiotensin converting enzyme 2
-
Mus musculus
3.4.17.23 angiotensin converting enzyme 2
-
Rattus norvegicus
3.4.17.23 hACE2
-
Homo sapiens