EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.17.23 | development of a transgenic mouse model (syn-hACE2) where the full open reading frame of the human ACE2 gene is under the control of a synapsin promoter, allowing the hACE2 protein to be expressed specifically in neurons | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.17.23 | Zn2+ | metallopeptidase | Homo sapiens | |
3.4.17.23 | Zn2+ | metallopeptidase | Mus musculus | |
3.4.17.23 | Zn2+ | metallopeptidase | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.17.23 | angiotensin II + H2O | Homo sapiens | the major role of ACE2 in Ang peptides metabolism is the production of Ang-(1-7). ACE2 also participates in the metabolism of other peptides non related to the renin-angiotensin system: apelin-13, neurotensin, kinetensin, dynorphin, [des-Arg9]-bradykinin, and [Lys-des-Arg9]-bradykinin | angiotensin-(1-7) + Phe | - |
? | |
3.4.17.23 | additional information | Homo sapiens | the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.17.23 | Homo sapiens | Q9BYF1 | - |
- |
3.4.17.23 | Mus musculus | Q8R0I0 | - |
- |
3.4.17.23 | Rattus norvegicus | Q5EGZ1 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.17.23 | brain | - |
Rattus norvegicus | - |
3.4.17.23 | brain | ACE2 is widespread throughout the brain, present in nuclei involved in the central regulation of cardiovascular function like the cardio-respiratory neurons of the brainstem, as well as in non-cardiovascular areas such as the motor cortex and raphe | Homo sapiens | - |
3.4.17.23 | brain | predominantly in neurons | Mus musculus | - |
3.4.17.23 | kidney | in salt-sensitive Sabra hypertensive (SBH/y) rats, ACE2 mRNA and protein expression are lower than that in salt-resistant Sabra normotensive (SBN/y) rats | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.17.23 | angiotensin I + H2O | the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited | Homo sapiens | angiotensin-(1-9) + Leu | - |
? | |
3.4.17.23 | angiotensin II + H2O | - |
Mus musculus | angiotensin-(1-7) + Phe | - |
? | |
3.4.17.23 | angiotensin II + H2O | - |
Rattus norvegicus | angiotensin-(1-7) + Phe | - |
? | |
3.4.17.23 | angiotensin II + H2O | the major role of ACE2 in Ang peptides metabolism is the production of Ang-(1-7). ACE2 also participates in the metabolism of other peptides non related to the renin-angiotensin system: apelin-13, neurotensin, kinetensin, dynorphin, [des-Arg9]-bradykinin, and [Lys-des-Arg9]-bradykinin | Homo sapiens | angiotensin-(1-7) + Phe | - |
? | |
3.4.17.23 | angiotensin II + H2O | ACE2 has approximately a 400fold greater affinity for Ang-II than Ang-I | Homo sapiens | angiotensin-(1-7) + Phe | - |
? | |
3.4.17.23 | additional information | the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited | Homo sapiens | ? | - |
? | |
3.4.17.23 | additional information | hydrolyses its substrates by removing a single amino acid from their respective C-terminal | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.17.23 | ACE 2 | - |
Homo sapiens |
3.4.17.23 | ACE 2 | - |
Mus musculus |
3.4.17.23 | ACE 2 | - |
Rattus norvegicus |
3.4.17.23 | Ang converting enzyme 2 | - |
Homo sapiens |
3.4.17.23 | Ang converting enzyme 2 | - |
Mus musculus |
3.4.17.23 | Ang converting enzyme 2 | - |
Rattus norvegicus |
3.4.17.23 | angiotensin converting enzyme 2 | - |
Homo sapiens |
3.4.17.23 | angiotensin converting enzyme 2 | - |
Mus musculus |
3.4.17.23 | angiotensin converting enzyme 2 | - |
Rattus norvegicus |
3.4.17.23 | hACE2 | - |
Homo sapiens |